Korean J Anesthesiol.  2002 Nov;43(5):572-574. 10.4097/kjae.2002.43.5.572.

The Effect of Pretreatment with Lidocaine for the Withdrawal Movement Associated with the Injection of Rocuronium in Children

• Kim KS
• Chae YJ
• Park SY
• Cho HB
• Kim JS

• KMID: 2091726
• DOI: http://doi.org/10.4097/kjae.2002.43.5.572

Abstract

BACKGROUND: The purpose of this study was two fold; first, to determine the incidence and type of withdrawal movement associated with IV injection of rocuronium in pediatric patients; and second, to determine whether pretreatment with IV lidocaine affects the incidence of movement associated with rocuronium administration in pediatric patients.
METHODS
Forty-two pediatric patients were randomly assigned to two groups. After general anesthesia was induced with thiopental sodium 5 mg/kg and manual occlusion of venous inflow was performed, one group of patients received 0.1 ml/kg 1% lidocaine IV. A second group received 0.1 ml/kg of normal saline as a placebo control. Venous inflow occlusion was held for 5 seconds, and immediately followed by the injection of rocuronium 0.6 mg/kg IV. The patient's response to rocuronium injection was graded using a 5-point scale.
RESULTS
We observed that the incidence of movement was 100% in the placebo group and was significantly decreased to 28.8% in the group pretreated with lidocaine (P<0.001).
CONCLUSIONS
Withdrawal movement on injection of rocuronium in pediatric patients can be decreased or prevented by pretreatment with IV lidocaine.

Keyword

Anesthetic; local; lidocaine; complication; movement; neuromuscular relaxants; rocuronium

MeSH Terms

Anesthesia, General
Child*
Humans
Incidence
Lidocaine*
Thiopental
Lidocaine
Thiopental