Korean J Anesthesiol.  1999 Jul;37(1):92-99. 10.4097/kjae.1999.37.1.92.

Altered Responses of IL-6 and IL-10 by the Ketorolac as an Adjunct to Patient-Controlled Morphine after bdominal Hysterectomy

• Kim MH
• Han TS
• Gwak MS

• KMID: 2236848
• DOI: http://doi.org/10.4097/kjae.1999.37.1.92

Abstract

BACKGROUND: In spite of adverse reactions, morphine has been used as a basic constituent for patient controlled analgesia (PCA). Because morphine affects various immune functions, PCA with morphine may deteriorate immune mechanisms further after surgery. In this study we decided to determine how different is the morphine PCA from the combination of morphine and ketorolac in Interleukin-6 (IL-6) and IL-10 responses, analgesia and side effects.
METHODS
Twenty two patients undergoing abdominal hysterectomy were randomly divided to two groups: PCA with morphine and PCA with the combination of morphine and ketorolac. Blood samples to measure cytokines were collected before induction of anesthesia, immediately after surgery, 1, 4, 24 h after PCA. Plasma was separated and frozen until the analysis of cytokines with ELISA. Postoperative pain was assessed using a visual analog score (VAS). Sedation was checked according to our protocol.
RESULTS
In both groups IL-6 response rose immediately after surgery and stayed increased until 24 h, and IL-10 level peaked at 1 h after PCA then progressively declined. In the comparison of cytokines between the two groups there were significant differences in IL-6 at 24 h (P=0.026) and IL-10 at 4 h after PCA (P=0.03). In morphine consumption between the two groups there were significant differences (P=0.037 at 4 after PCA, P=0.015 at 24 h after PCA), however, pain scores, sedation and side effects were unaffected by the PCA regimen.
CONCLUSIONS
We conclude that the supplementation of ketorolac with morphine modify the cytokine responses and in this way may contribute immune alterations during post-operative period.

Keyword

Cytokine, IL-6, IL-10; Patient controlled analgesia, ketorolac, morphine

MeSH Terms

Analgesia
Analgesia, Patient-Controlled
Anesthesia
Cytokines
Enzyme-Linked Immunosorbent Assay
Humans
Hysterectomy*
Interleukin-10*
Interleukin-6*
Ketorolac*
Morphine*
Pain, Postoperative
Passive Cutaneous Anaphylaxis
Plasma
Cytokines
Interleukin-10
Interleukin-6
Ketorolac
Morphine