Korean J Anesthesiol.  2003 Jul;45(1):37-41. 10.4097/kjae.2003.45.1.37.

The Effect of Intravenous Ketamine on Recovery from Total Intravenous Anesthesia with Propofol

• Kim SB
• Park HJ
• Kim ST
• Kang H
• Lim SW

• KMID: 2236736
• DOI: http://doi.org/10.4097/kjae.2003.45.1.37

Abstract

BACKGROUND: The aim of this study was to evaluate the effects of the continuous infusion of ketamine on recovery characteristics after total intravenous anesthesia (TIVA) with propofol.
METHODS
Fifty-six patients undergoing tympanoplasty were randomly allocated to group I (control, n = 20), group II (ketamine 0.3 microgram/ml, n = 16) or group III (ketamine 0.6 microgram/ml, n = 20). Ketamine and propofol were continuously administered by using target-controlled infusion (TCI) at different ketamine steady-state concentrations. Blood pressure, heart rate and the time interval from the discontinuation of propofol to eye opening and discharge were measured.
RESULTS
The changes in mean arterial pressure and heart rate before and after auditory ossicles movement examination were larger in group I than in group II or in group III (P <0.05). And, the times to eye opening and to discharge from the recovery room were longer in group II and group III than in group I (P <0.05). Hallucination occurred only in seven patients of group III.
CONCLUSIONS
Groups II and III were more stable hemodynamically than group I, but patients in groups II and III required a longer recovery time than group I. No hallucination was found in groups I and II. We conclude that when ketamine is administered in combination with propofol, a lesser concentration than 0.3 microgram/ml of ketamine or early discontinuation of ketamine infusion appear to be appropriate.

Keyword

ketamine; propofol; total intravenous anesthesia; recovery

MeSH Terms

Anesthesia, Intravenous*
Arterial Pressure
Blood Pressure
Ear Ossicles
Hallucinations
Heart Rate
Humans
Ketamine*
Propofol*
Recovery Room
Tympanoplasty
Ketamine
Propofol