Korean J Anesthesiol.  2012 Sep;63(3):195-202. 10.4097/kjae.2012.63.3.195.

Current therapeutic agents and anesthetic considerations for diabetes mellitus

• Kang H

• KMID: 2236267
• DOI: http://doi.org/10.4097/kjae.2012.63.3.195

Abstract

As the incidence of diabetes mellitus (DM) continues to increase worldwide, more diabetic patients will be presented for surgery and anesthesia. This increase of DM is a consequence of the rise in new patients of type 2 DM, and is likely attributable to rapid economic development, improved living standards, aging population, obesity, and lack of exercise. The primary goal of management in DM is to delay, or prevent the macro- and microvascular complications by achieving good glycemic control. More understanding of the pathophysiology of DM has contributed to the advance of new pharmacological approaches. In addition to the conventional therapy for DM, glucagon-like peptide-1 (GLP-1) mimetics, dipeptidyl peptidase-4 (DPP-4) inhibitors, thiazolidinediones (TZDs), and insulin analogues are currently available effective hypoglycemic agents for the management of the patients with DM in the perioperative period and also consider the adverse effects of newly introduced agents that need more clinical observations.

Keyword

Anesthesia; Diabetes mellitus; Glucose; Hypoglycemia; Treatment

MeSH Terms

Aging
Anesthesia
Diabetes Mellitus
Economic Development
Glucagon-Like Peptide 1
Glucose
Humans
Hypoglycemia
Hypoglycemic Agents
Incidence
Insulin
Obesity
Perioperative Period
Socioeconomic Factors
Thiazolidinediones
Glucagon-Like Peptide 1
Glucose
Hypoglycemic Agents
Insulin
Thiazolidinediones