Int Neurourol J.  2014 Sep;18(3):106-114. 10.5213/inj.2014.18.3.106.

Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis

• Fiehn O
• Kim J

• KMID: 2232937
• DOI: http://doi.org/10.5213/inj.2014.18.3.106

Abstract

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency in the absence of bacterial infection or identifiable clinicopathology. IC can lead to long-term adverse effects on the patient's quality of life. Therefore, early diagnosis and better understanding of the mechanisms underlying IC are needed. Metabolomic studies of biofluids have become a powerful method for assessing disease mechanisms and biomarker discovery, which potentially address these important clinical needs. However, limited intensive metabolic profiles have been elucidated in IC. The article is a short review on metabolomic analyses that provide a unique fingerprint of IC with a focus on its use in determining a potential diagnostic biomarker associated with symptoms, a response predictor of therapy, and a prognostic marker.

Keyword

Interstitial cystitis; Metabolomics; Biological markers; Magnetic resonance spectroscopy; Mass spectrometry

MeSH Terms

Bacterial Infections
Biomarkers
Cystitis, Interstitial*
Dermatoglyphics
Early Diagnosis
Magnetic Resonance Spectroscopy
Mass Spectrometry
Metabolome
Metabolomics*
Pelvic Pain
Quality of Life
Urinary Bladder
Urinary Tract