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Prediction of Drug–Drug Interactions by Using Profile Fingerprint Vectors and Protein Similarities

Dere S, Ayvaz S

OBJECTIVES: Drug–drug interaction (DDI) is a vital problem that threatens people's health. However, the prediction of DDIs through in-vivo experiments is not only extremely costly but also difficult as many...
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Diagnosis and Management of Hip Dislocation in Patients with Kabuki Syndrome

Lim C, Jung ST, Shin CH, Park MS, Yoo WJ, Chung CY, Choi IH, Ko JM, Cho TJ

BACKGROUND: Kabuki syndrome is a rare genetic disorder characterized by distinct dysmorphic facial features, growth deficiency, intellectual disabilities, unusual dermatoglyphic patterns, and skeletal abnormalities. The incidence of hip dislocation in...
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LGR5 and Downstream Intracellular Signaling Proteins Play Critical Roles in the Cell Proliferation of Neuroblastoma, Meningioma and Pituitary Adenoma

Hwang M, Han MH, Park HH, Choi H, Lee KY, Lee YJ, Kim JM, Cheong JH, Ryu JI, Min KW, Oh YH, Ko Y, Koh SH

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) has been reported to play critical roles in the proliferation of various cancer cells. However, the roles of LGR5 in brain tumors and...
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Distinct Urinary Metabolic Profile in Rheumatoid Arthritis Patients: A Possible Link between Diet and Arthritis Phenotype

Koh JH, Park YJ, Lee S, Hong YS, Hong KS, Yoo SA, Cho CS, Kim WU

OBJECTIVE: We undertook this study to investigate the discriminant metabolites in urine from patients with established rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and from healthy individuals. METHODS: Urine samples were...
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Application of Metabolomics to Quality Control of Natural Product Derived Medicines

Lee KM, Jeon JY, Lee BJ, Lee H, Choi HK

Metabolomics has been used as a powerful tool for the analysis and quality assessment of the natural product (NP)-derived medicines. It is increasingly being used in the quality control and...
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MALDI-TOF-MS Fingerprinting Provides Evidence of Urosepsis caused by Aerococcus urinae

Kim J, Hong SK, Kim M, Yong D, Lee K

Urosepsis due to Aerococcus urinae is rare in clinical settings with only a few of reported cases worldwide by 16S rRNA sequencing. Here we report a case of sepsis caused...
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Colonic Transit Time Is a Driven Force of the Gut Microbiota Composition and Metabolism: In Vitro Evidence

Tottey W, Feria-Gervasio D, Gaci N, Laillet B, Pujos E, Martin JF, Sebedio JL, Sion B, Jarrige JF, Alric M, Brugère J

  • KMID: 2367464
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):124-134.
  • doi: 10.5056/jnm16042
BACKGROUND/AIMS: Human gut microbiota harbors numerous metabolic properties essential for the host's health. Increased intestinal transit time affects a part of the population and is notably observed with human aging,...
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Taxonomic Identification of Bacillus Species Using Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry

Yu WS, Lee KM, Hwang KJ

BACKGROUND: In this study, we compared various methods of taxonomic identification of Bacillus strains: biochemical methods, 16S rRNA gene sequencing, and matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF MS)....
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Raman Spectroscopy for the Endoscopic Diagnosis of Esophageal, Gastric, and Colonic Diseases

Sharma N, Takeshita , Ho KY

Globally white-light endoscopy with biopsy sampling is the gold standard diagnostic modality for esophageal, gastric, and colonic pathologies. However, there is overwhelming evidence to highlight the deficiencies of an approach...
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Hansen's fingerprints in bone marrow histiocytes

Sharma R, Ramdas A

No abstract available.
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Sonchus asper extract inhibits LPS-induced oxidative stress and pro-inflammatory cytokine production in RAW264.7 macrophages

Wang L, Xu ML, Liu J, Wang Y, Hu JH, Wang MH

BACKGROUND/OBJECTIVES: Sonchus asper is used extensively as an herbal anti-inflammatory for treatment of bronchitis, asthma, wounds, burns, and cough; however, further investigation is needed in order to understand the underlying...
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Anti-inflammatory Activities of Lupane-triterpenoids In Vitro and Their Phytochemical Fingerprinting from Leaves of Acanthopanax gracilistylus

Li XJ, Dai L, Li Z, Zhang XD, Liu XQ, Zou QP, Xie X

The activities on the inhibition of NO on LPS-induced RAW 264.7 macrophages were investigated in this work. A simple and sensitive method has been developed and validated for fingerprinting analysis...
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Concept and importance of patient identification for patient safety

Yum H

Patient identification (PI) errors have been one of the most serious global healthcare quality issues for patient safety. Errors in PI are the root causes of many adverse events. Patient...
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Recurrent Pseudomonas aeruginosa Infection in Chronic Lung Diseases: Relapse or Reinfection?

Yum HK, Park IN, Shin BM, Choi SJ

BACKGROUND: Pseudomonas aeruginosa infection is particularly associated with progressive and ultimately chronic recurrent respiratory infections in chronic obstructive pulmonary disease, bronchiectasis, chronic destroyed lung disease, and cystic fibrosis. Its treatment...
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Metabolomics Insights Into Pathophysiological Mechanisms of Interstitial Cystitis

Fiehn O, Kim J

Interstitial cystitis (IC), also known as painful bladder syndrome or bladder pain syndrome, is a chronic lower urinary tract syndrome characterized by pelvic pain, urinary urgency, and increased urinary frequency...
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Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors

Chee HK, Oh SJ

The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors....
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Direct Analysis in Real Time Mass Spectrometry (DART-MS) Analysis of Skin Metabolome Changes in the Ultraviolet B-Induced Mice

Park HM, Kim HJ, Jang YP, Kim SY

  • KMID: 2170665
  • Biomol Ther.
  • 2013 Nov;21(6):470-475.
Ultraviolet (UV) radiation is a major environmental factor that leads to acute and chronic reactions in the human skin. UV exposure induces wrinkle formation, DNA damage, and generation of reactive...
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Analytical Tools and Databases for Metagenomics in the Next-Generation Sequencing Era

Kim M, Lee KH, Yoon SW, Kim BS, Chun J, Yi H

Metagenomics has become one of the indispensable tools in microbial ecology for the last few decades, and a new revolution in metagenomic studies is now about to begin, with the...
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Molecular Typing of Cryptococcus neoformans Isolated from Korean Patients

Park SH, Cho SI, Hwang SM

Cyptococcosis is generally caused by Cryptococcus neoformans, the opportunistic agent which has two species such as C. neoformans and C. gattii. Both C. neoformans and C. gattii species contain a...
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A Fosmid Cloning Strategy for Detecting the Widest Possible Spectrum of Microbes from the International Space Station Drinking Water System

Choi S, Chang MS, Stuecker T, Chung C, Newcombe D, Venkateswaran K

In this study, fosmid cloning strategies were used to assess the microbial populations in water from the International Space Station (ISS) drinking water system (henceforth referred to as Prebiocide and...
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