Int Neurourol J.  2014 Mar;18(1):10-15.

Toll-Like Receptor 10-1-6 Gene Cluster Polymorphisms Are Not Associated With Benign Prostatic Hyperplasia in Korean Population

• Kim SK
• Kim YO
• Lee BC
• Yoo KH
• Chung JH

Abstract

PURPOSE
Inflammation and infection have been associated with the pathogenesis of benign prostatic hyperplasia (BPH). Toll-like receptors (TLRs) play key roles in the innate immune system and initiate the inflammatory response to foreign pathogens. We investigated the relationship between TLR10-1-6 gene cluster polymorphisms and BPH.
METHODS
We genotyped four promoter single nucleotide polymorphisms (SNPs) (TLR10, rs10004195; TLR1, rs5743557; and TLR6, rs1039560 and rs1039559) by directly sequencing (233 BPH patients and 214 control subjects). SNPStats and Haploview version 4.02 were used to analyze the data. Multiple logistic regression models (log-additive, dominant, and recessive) were performed to determine odds ratios (ORs), 95% confidence intervals (CIs), and P-values.
RESULTS
The genotype and allele frequencies of each SNP was not different between the BPH and control groups (P>0.05). Haplotype analysis showed no association between the haplotype in the linkage disequilibrium (LD) block and BPH (P>0.05), although the LD block was constructed.
CONCLUSIONS
These results indicate that the TLR10-1-6 gene cluster may be not associated with the development of BPH in the Korean population.

Keyword

Prostatic hyperplasia; Single nucleotide polymorphism; Toll-like receptors

MeSH Terms

Gene Frequency
Genotype
Haplotypes
Humans
Immune System
Inflammation
Linkage Disequilibrium
Logistic Models
Multigene Family*
Odds Ratio
Polymorphism, Single Nucleotide
Prostatic Hyperplasia*
Toll-Like Receptors*
Toll-Like Receptors