Int Neurourol J.  2011 Sep;15(3):127-134.

Exploring the Potential of Flunarizine for Cisplatin-Induced Painful Uremic Neuropathy in Rats

• Muthuraman A
• Singla SK
• Peters A

Abstract

PURPOSE
The present study was designed to explore the potential of flunarizine for cisplatin induced painful uremic neuropathy in rats.
METHODS
Cisplatin (2 mg/kg; i.p., for 5 consecutive days) was administered and renal uremic markers i.e., serum creatinine were estimated on days 4 and 25. Behavioral changes were assessed in terms of thermal hyperalgesia (hot plate, plantar, tail immersion, and tail flick tests at different time intervals). Biochemical analysis of total calcium, superoxide anion, DNA, and transketolase, and myeloperoxidase activity in tissue samples was also performed. Furthermore, flunarizine (100, 200, and 300 microM/kg; p.o., for 21 consecutive days) was administered to evaluate its potency on uremic neuropathy, and the results were compared with those for the carbamazepine-treated (30 mg/kg; p.o., for 21 consecutive days) groups.
RESULTS
Flunarizine attenuated the cisplatin-induced uremic neuropathy, and the degree of behavioral and biochemical changes in serum and tissue samples in a dose dependent manner. The medium and high doses of flunarizine were shown to produce a significant effect on cisplatin induced painful uremic neuropathy.
CONCLUSIONS
Our results indicate the potential of flunarizine for anti-oxidative, anti-inflammatory, and neuroprotective actions. Therefore, it may have use as a novel therapeutic agent for the management of painful uremic neuropathy.

Keyword

Hyperalgesia; Peroxidase; Neurotoxins; Transketolase; Uremia

MeSH Terms

Animals
Calcium
Cisplatin
Creatinine
DNA
Flunarizine
Hyperalgesia
Immersion
Neurotoxins
Peroxidase
Rats
Superoxides
Transketolase
Uremia
Calcium
Cisplatin
Creatinine
DNA
Flunarizine
Neurotoxins
Peroxidase
Superoxides
Transketolase