J Korean Acad Rehabil Med.  2003 Feb;27(1):90-95.

The Preventive Effect of Nimodipine on the Cisplatin Induced Neuropathy

• Kim CH
• Choi HC
• Roh GH

Abstract

OBJECTIVE
Cisplatin has effectiveness in the treatment of solid tumor by active cytotoxic action, but with significant side effects such as peripheral neuropathy. To investigate the prevention of neuropathy, nimodipine was examined. METHOD: Fifty female rats (Sprague-Dawley strain; BW 210-260 g, 12-15 week old) were used: control group; cisplatin group; cisplatin-nimodipine 2 week group, 10; ciplatin-nimodipine 4 week group; base group. Peripheral neuropathy was induced by intraperitoneal injection of the cisplatin (0.04 mg/ml, 1 ml/kg/ip/ for 2 weeks). Nimodipine was injected intraperitoneally for 2 weeks and 4 weeks in cisplatin-nimodipine 2 week group and cisplatin-nimodipine 4 week group, respectively. Motor and sensory nerve conduction studies were done using in rat tail nerve from the beginning and biweekly till to 10th week. RESULTS: Weight reduction was significant in cisplatin group at 2nd week (p<0.05). The latencies of motor and sensory nerves were delayed in 2nd, 4th week in all groups with cisplatin (p<0.05) and the recovered after 6th week in all groups. The amplitudes of motor and sensory nerves in these groups haven't made any difference compared with control group (p>0.05). CONCLUSION: The neurotoxicity of cisplatin revealed in motor and sensory neurons. The neuropathy has recovered to control value in 6th week and the preventive effect of nimodipine was transient.

Keyword

Cisplatin; Neuropathy; Nimodipine

MeSH Terms

Animals
Cisplatin*
Female
Humans
Injections, Intraperitoneal
Neural Conduction
Nimodipine*
Peripheral Nervous System Diseases
Rats
Sensory Receptor Cells
Tail
Weight Loss
Cisplatin
Nimodipine