Int Neurourol J.  2011 Sep;15(3):120-126.

Dissimilar Effects of Tolterodine on Detrusor Overactivity in Awake Rats with Chemical Cystitis and Partial Bladder Outlet Obstruction

• Jin LH
• Park CS
• Shin HY
• Yoon SM
• Lee T

Abstract

PURPOSE
We investigated bladder function, with a special focus on nonvoiding contractions (NVCs), in awake rats with chronic chemical cystitis and bladder outlet obstruction (BOO) by use of simultaneous registrations of intravesical and intraabdominal pressures. In addition, we tested the effects of tolterodine on the NVCs in these models.
METHODS
A total of 20 female Sprague-Dawley rats were used in this study. In eight rats, chemical cystitis was induced by intravesical instillation of HCl. Twelve rats were subjected to sham instillations or partial BOO. Four weeks after intravesical instillation or 2 weeks after partial BOO, cystometrograms were obtained by use of simultaneous recording of intravesical and intraabdominal pressure in all unanesthetized, unrestrained rats in metabolic cages.
RESULTS
A total of 17 rats survived. In the rats with acute injury by HCl, 50% showed detrusor overactivity (DO), which was not seen in the sham group. The cystitis group had lower DO pressure without a difference in DO frequency compared with the BOO group. After the administration of tolterodine, the cystitis group showed no difference in DO frequency or pressure, whereas the BOO group showed decreased values for both parameters.
CONCLUSIONS
Our study showed that toleterodine produced no effect on DO during the filling phase in rats with chronic chemical cystitisbut decreased the frequency and pressure of DO in rats with BOO. Clinically, studies are needed to improve the treatment effect of anticholinergic drugs ininterstitial cystitis patients with overactive bladder.

Keyword

Overactive urinary bladder; Urodynamics; Rats

MeSH Terms

Administration, Intravesical
Animals
Benzhydryl Compounds
Contracts
Cresols
Cystitis
Female
Humans
Phenylpropanolamine
Rats
Rats, Sprague-Dawley
Salicylamides
Tolterodine Tartrate
Urinary Bladder
Urinary Bladder Neck Obstruction
Urinary Bladder, Overactive
Urodynamics
Benzhydryl Compounds
Cresols
Phenylpropanolamine
Salicylamides