Int Neurourol J.
2014 Dec;18(4):179-186. 10.5213/inj.2014.18.4.179.
Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia
- Affiliations
-
- 1Kohwang Medical Research Institute, Kyung Hee University School of Medicine, Seoul, Korea.
- 2Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, Seoul, Korea.
- 3Herbal Crop Utilization Research Team, Department of Medicinal Crop Research Institute, Eumseong, Korea. kyo9128@korea.kr
- 4Mushroom Research Division, National Institute of Horticulture & Herbal Science, Rural Administration, Eumseong, Korea.
- KMID: 2232731
- DOI: http://doi.org/10.5213/inj.2014.18.4.179
Abstract
- PURPOSE
Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng) on a rat model of testosterone-induced BPH.
METHODS
The rats were divided into 3 groups (each group, n=10): control, testosterone-induced BPH (20 mg/kg, subcutaneous injection), and P. ginseng (200 mg/kg, orally) groups. After 4 weeks, all animals were sacrificed to examine the blood biochemical profiles, prostate volume, weight, histopathological changes, alpha-1D adrenergic receptor (Adra1d) mRNA expression, and epidermal growth factor receptor (EGFR) and B-cell CLL/lymphoma 2 (BCL2) protein expression.
RESULTS
The group treated with P. ginseng showed significantly lesser prostate size and weight than the testosterone-induced BPH group. In addition, P. ginseng decreased the mRNA expression of Adra1d as well as the expression of EGFR and BCL2 in prostate tissue.
CONCLUSIONS
These results suggest that P. ginseng may inhibit the alpha-1-adrenergic receptor to suppress the development of BPH.
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