Korean J Dermatol.  1983 Apr;21(2):225-229.

Leiomyosarcoma of the Skin: Report of A Case

Abstract

Leiomyosarcoma arising in the skin is rare tumor, and diagnosis usually is made microscopically. After local excision, these lesions recur in large proportion of pat ients. The authors herein report a 53-year-old male with leiomyosarcoma appeared in the skin of the right forearm and presenting as a dark reddish colored, 5*6cm in diameter, superficial ulcerated single firm nodule with intermittent pain. Histopathological examination showed poorly circumscribed tumor consisting of interlacing bundles of spindle shaped smooth muscle cells in the middle and lower parts of the dermis. The nuclei were hyperchromatic, large, vacuolated, and irregular in shape. Electron microscopic findings revealed cytoplasmic organelles such as rough endoplasmic reticulum and mitochondria of malignant smooth muscle cells in the paranuclear area, Characteristic subsarcoelmmal caveolae and dense plaque were noted and myofilaments were distributed in the peripheral cytoplasm. The tumor did not recur in 10 months' follow-up.


MeSH Terms

Caveolae
Cytoplasm
Dermis
Diagnosis
Endoplasmic Reticulum, Rough
Follow-Up Studies
Forearm
Humans
Leiomyosarcoma*
Male
Middle Aged
Mitochondria
Myocytes, Smooth Muscle
Myofibrils
Organelles
Skin*
Ulcer
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