Korean J Dermatol.  1992 Jun;30(3):334-339.

Effect of dietary zinc deficiency on the enzymatic components of free radical defense system in the skin of rats

• Kim DK
• Koo SW
• Lee ES
• Lee JB

Abstract

The effect of dietary zinc deficiency on the enzymatic components of free radical defense system was observed in the skin of rats. We measured the concentration of serum zinc and the enzymatic activities of CuZn superoxide dismutase(CuZn SOD), glucose-6-phosphate dehydrogenase(GGPDH) and glutathione reductase (GSH-RD). The serum zinc level was sig nificantly lower in the zinc-deficient group compared to the zinc-supplemented group after 8 weeks of consuming the diet(P<0.01). CuZn SOD activity was not different between the two groups after 4 weeks. The Zn deficient group showed the significantly decreased activity of G6PDH after 4 and 8 weeks of consuming the diet(P<0.01). The activity of GSH-RD was increased in the zinc-deficient group compared to the supplemented group after 4 weeks of consuming the diet(P<0.01), but after 8 weeks the activity was not different between the two groups. From the results obtained, it could be concluded that GSH-RD may contribute to the oxygen free radical defense system in zinc deficiency in the earlier weeks of consum ing the zinc-deficient diet.

Keyword

CuZn SOD; Free radical defense; Glucose-6-phosphate dehydrogenase; Glutathione reductase; Zn deficiency

MeSH Terms

Animals
Diet
Glucose-6-Phosphate
Glucosephosphate Dehydrogenase
Glutathione Reductase
Oxygen
Rats*
Skin*
Superoxides
Zinc*
Glucose-6-Phosphate
Glucosephosphate Dehydrogenase
Glutathione Reductase
Oxygen
Superoxides
Zinc