Korean Circ J.  1988 Mar;18(1):153-158. 10.4070/kcj.1988.18.1.153.

Clinical Study on Antihypertensive Effect of Verapamil

• Seo BK
• Lee JS

• KMID: 2229602
• DOI: http://doi.org/10.4070/kcj.1988.18.1.153

Abstract

The antihypertensive effect of verapamil, a calcium channel blocker, was studied in 12 cases of essential hypertension (mean age 49, range 24-64). After 6 weeks administration (80-160mg t.i.d.), the following results were obtained : 1) Before medication, average systolic and diastolic blood pressure was 176.3/108.6mmHg. After completion of therapy, blood presure fell significantly down to 154.8/94.2mmHg (p<0.01). 2) Heart rate decreased slightly from average 74.3 per minute prior to medication to 69.3 per minute at the end of study (p<0.01). 3) Side effects, among which constipation was most common, were mild and did not compel any patient to diacontinue therapy. In conclusion, verapamil seems to be a safe and effective first-line drug for hypertension along with diuretics or beta blockers.

Keyword

Verapamil; Antihypertensive effect

MeSH Terms

Blood Pressure
Calcium Channels
Constipation
Diuretics
Heart Rate
Humans
Hypertension
Verapamil*
Calcium Channels
Diuretics
Verapamil