Total Antioxidant Capacities in Patients with End Stage Renal Disease and Effect of Hemodialysis

Chun, Sail; Kim, Soon Bae; Min, Won Ki

Abstract

BACKGROUND: Cardiovascular disease is the major cause of mortality in patients receiving hemodialysis(HD) for end stage renal disease(ESRD). After renal failure, antioxidant levels increase, possibly in response to increased generation of free radicals. As a result, increased lipid peroxidation may contribute to increased risks of atherosclerosis. The aims of this study was to investigate the distribution of total antioxidant capacity of plasma in Korean adults and ESRD patients, and effects of HD.
METHODS
Ninety five patients(41 men and 54 women, mean ages 54.7+/-28.3 years) receiving regular HD for ESRD were recruited. Venous blood samples were taken immediately before HD in 65 patients, and before and after HD in 30 patients. Control subjects were healthy individuals(61 men and 51 women, mean ages 42.7+/-10.8 years). Total antioxidant capacity of plasma and serum uric acid concentration were assessed.
RESULTS
Reference range of plasma total antioxidant capacity in Korean population is 1.04 ~ 1.52 mmol/L. Total antioxidant capacities in male(1.32+/-0.11 mmol/L; mean+/-SD) were higher than those of female(1.24+/-0.12 mmol/L, P<0.001). Total antioxidant capacities in ESRD patients(1.72+/-0.26 mmol/L) were higher than controls(1.28+/-0.12 mmol/L, P<0.001). Total antioxidant capacities in pre-HD samples(1.55+/-0.16 mmol/L) were higher than post-HD(1.33+/-0.10 mmol/L). Plasma total antioxidant capacities and serum uric acid concentrations showed positive correlation(r = 0.69, P < 0.0001). DISCUSSION: The increase in total antioxidant capacity in ESRD patients might be due to high serum uric acid. Plasma total antioxidant capacities decreased after HD in ESRD patients due to decrease of uric acid concentration.