Korean Circ J.  2011 Nov;41(11):674-676. 10.4070/kcj.2011.41.11.674.

Wolff-Parkinson-White Syndrome in a Patient With Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes Syndrome

• Lee MH
• Sung YJ
• Yoon JH
• Kim J
• Oh IY
• Choi EK
• Oh S

• KMID: 2225077
• DOI: http://doi.org/10.4070/kcj.2011.41.11.674

Abstract

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) syndrome is a multisystem disorder, which is clinically characterized by encephalopathy, dementia, seizures and stroke-like episodes. Multiple organs can be affected and cardiac involvement often dominates the clinical picture because of its high energy requirement. We report a case of a 21-year-old woman with MELAS syndrome who had pre-excitation ECG and one episode of tachycardia attack.

Keyword

MELAS syndrome; Wolff-Parkinson-White syndrome

MeSH Terms

Acidosis, Lactic
Dementia
Electrocardiography
Female
Humans
MELAS Syndrome
Mitochondrial Encephalomyopathies
Seizures
Tachycardia
Wolff-Parkinson-White Syndrome
Young Adult
Mitochondrial Encephalomyopathies

Figure

• 

  Fig. 1 Axial T2 brain MRI scan revealed infarction in the right temporal lobe, ischemia in the left posterior frontoparietal cortex and basal ganglia.

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  Fig. 2 Hematoxylin-eosin staining showed small angulated muscle fibers with variations in size suggesting neurogenic atrophy and slightly increased lipid vacuoles in the subsarcolemmal area.

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  Fig. 3 Electrocardiography revealed a short PR interval, delta wave and widened QRS complex which were compatible with WPW syndrome.

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