J Rheum Dis.  2014 Feb;21(1):46-49. 10.4078/jrd.2014.21.1.46.

Acute Precursor T Cell Lymphoblastic Leukemia Associated with Behcet's Disease: A Case Report

Affiliations
  • 1Division of Rheumatology, Department of Internal Medicine, Korea University Medical College, Seoul, Korea. lyhcgh@korea.ac.kr

Abstract

Behcet's disease is an inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. A few cases of hematologic disease in patients with Behcet's disease have been reported in the literature. However, acute precursor T cell lymphoblastic leukemia has never been described in association with Behcet's disease. We recently encountered a case of acute precursor T cell lymphoblastic leukemia in a 62-year-old man with a prior diagnosis of Behcet's disease. The patient presented with febrile neutropenia and his bone marrow biopsy revealed acute precursor T cell lymphoblastic leukemia. He was scheduled to undergo therapeutic chemotherapy, but unfortunately he died from pneumonia prior to treatment.

Keyword

Behcet's disease; Acute precursor T cell lymphoblastic leukemia

MeSH Terms

Biopsy
Bone Marrow
Diagnosis
Drug Therapy
Febrile Neutropenia
Hematologic Diseases
Humans
Middle Aged
Pneumonia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*
Skin
Stomatitis, Aphthous
Ulcer
Uveitis

Figure

  • Figure 1. Endoscopic findings show a deep ulcer beneath the ileal opening.

  • Figure 2. Peripheral blood smear shows abnormal cell (arrow) (H&E stain, ×1,000).

  • Figure 3. Bone marrow aspiration shows leukemic blasts with variable size (A, H&E stain, ×400). Leukemic blasts show irregular nuclei, and indistinct nucleoli (arrows) (B, H&E stain, ×1,000).


Reference

References

1. Sakane T, Takeno M, Suzuki N, Inaba G. Behç et's disease. N Engl J Med. 1999; 341:1284–91.
2. Yurdakul S, Yazici H. Behç et's syndrome. Best Pract Res Clin Rheumatol. 2008; 22:793–809.
3. Kim JW, Lee SH, Song R, Lee YA, Hong SJ, Yang HI. A case of Behcet's disease associated with myelofibrosis. J Rheum Dis. 2012; 19:55–8.
4. Senel S, Kaya E, Aydogdu I, Erkurt MA, Kuku I. Rheumatic diseases and chronic myelogenous leukemia, presentation of four cases and review of the literature. Rheumatol Int. 2006; 26:857–61.
Article
5. Ohno E, Ohtsuka E, Watanabe K, Kohno T, Takeoka K, Saburi Y, et al. Behç et's disease associated with myelodysplastic syndromes. A case report and a review of the literature. Cancer. 1997; 79:262–8.
6. Lin YC, Liang TH, Chang HN, Lin JS, Lin HY. Behç et disease associated with myelodysplastic syndrome. J Clin Rheumatol. 2008; 14:169–74.
7. Criteria for diagnosis of Behçet's disease. International Study Group for Behç et's Disease. Lancet. 1990; 335:1078–80.
8. Hemminki K, Liu X, Försti A, Ji J, Sundquist J, Sundquist K. Subsequent leukaemia in autoimmune disease patients. Br J Haematol. 2013; 161:677–87.
Article
9. Rama I, Grinyó JM. Malignancy after renal transplantation: the role of immunosuppression. Nat Rev Nephrol. 2010; 6:511–9.
Article
10. Kaushansky K, Lichtman M, Beutler E, Kipps T, Prchal J, Seligsohn U. Williams Hematology. 8th ed.p. 1409–30. New York: McGraw-Hill Professional;2010.
11. Aifantis I, Raetz E, Buonamici S. Molecular pathogenesis of T-cell leukaemia and lymphoma. Nat Rev Immunol. 2008; 8:380–90.
Article
12. Ozdogu H, Boga C, Yilmaz Z, Sahin FI, Bal N. Longterm colchicine therapy in a patient with Behç et's disease and acute promyelocytic leukemia. Rheumatol Int. 2007; 27:763–5.
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