J Rheum Dis.  2014 Feb;21(1):46-49. 10.4078/jrd.2014.21.1.46.

Acute Precursor T Cell Lymphoblastic Leukemia Associated with Behcet's Disease: A Case Report

• Kim JW
• Pyo JH
• Kim KJ
• Kim H
• Jeoung Y
• Ji JD
• Lee YH

• KMID: 2222990
• DOI: http://doi.org/10.4078/jrd.2014.21.1.46

Abstract

Behcet's disease is an inflammatory disorder characterized by recurrent oral aphthous ulcers, genital ulcers, uveitis, and skin lesions. A few cases of hematologic disease in patients with Behcet's disease have been reported in the literature. However, acute precursor T cell lymphoblastic leukemia has never been described in association with Behcet's disease. We recently encountered a case of acute precursor T cell lymphoblastic leukemia in a 62-year-old man with a prior diagnosis of Behcet's disease. The patient presented with febrile neutropenia and his bone marrow biopsy revealed acute precursor T cell lymphoblastic leukemia. He was scheduled to undergo therapeutic chemotherapy, but unfortunately he died from pneumonia prior to treatment.

Keyword

Behcet's disease; Acute precursor T cell lymphoblastic leukemia

MeSH Terms

Biopsy
Bone Marrow
Diagnosis
Drug Therapy
Febrile Neutropenia
Hematologic Diseases
Humans
Middle Aged
Pneumonia
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*
Skin
Stomatitis, Aphthous
Ulcer
Uveitis

Figure

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  Figure 1. Endoscopic findings show a deep ulcer beneath the ileal opening.

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  Figure 2. Peripheral blood smear shows abnormal cell (arrow) (H&E stain, ×1,000).

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  Figure 3. Bone marrow aspiration shows leukemic blasts with variable size (A, H&E stain, ×400). Leukemic blasts show irregular nuclei, and indistinct nucleoli (arrows) (B, H&E stain, ×1,000).

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