J Rheum Dis.  2015 Dec;22(6):405-406. 10.4078/jrd.2015.22.6.405.

Cryoglobulinemia with a Digital Gangrene from Monoclonal Gammopathy of Undetermined Significance

• Jeon CH

• KMID: 2222818
• DOI: http://doi.org/10.4078/jrd.2015.22.6.405

Abstract

No abstract available.

MeSH Terms

Cryoglobulinemia*
Gangrene*
Monoclonal Gammopathy of Undetermined Significance*
Paraproteinemias*

Figure

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  Figure 1. There was gangrene of the left second toe. Other toes also showed mild cyanotic change on their tips with a background of livedo reticularis.

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  Figure 2. On peripheral blood smear, after incubation in room temperature, extracellular pale pink amorphous materials were observed (Wright-Giemsa stain, ×200).

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  Figure 3. A bone marrow biopsy showed a normal myeloid to erythroid ratio and the usual maturation pattern but multifocal aggregates of plasma cells were observed (Wright-Giemsa stain, ×400).

Reference

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2. Dispenzieri A, Katzmann JA, Kyle RA, Larson DR, Melton LJ 3rd, Colby CL, et al. Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study. Lancet. 2010; 375:1721–8.

3. Terrier B, Karras A, Kahn JE, Le Guenno G, Marie I, Benar-ous L, et al. The spectrum of type I cryoglobulinemia vasculitis: new insights based on 64 cases. Medicine (Baltimore). 2013; 92:61–8.

4. Kyle RA, Buadi F, Rajkumar SV. Management of monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Oncology (Wil-liston Park). 2011; 25:578–86.