Blood Res.  2013 Sep;48(3):228-230. 10.5045/br.2013.48.3.228.

Concomitant transformation of monoclonal gammopathy of undetermined significance to multiple myeloma and of essential thrombocythemia to acute biphenotypic leukemia 37 years after initial diagnosis

• Niscola P
• Catalano G
• Fratoni S
• Scaramucci L
• de Fabritiis P
• Caravita T

• KMID: 2270712
• DOI: http://doi.org/10.5045/br.2013.48.3.228

Abstract

No abstract available.

MeSH Terms

Leukemia, Biphenotypic, Acute
Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Paraproteinemias
Thrombocythemia, Essential

Figure

• 

  Fig. 1 (A) Bone marrow (BM) biopsy shows increased immature precursors and dysmegakaryopiesis. (B) CD34 immunostain reveals 20% blasts. (C) Clusters of plasma cells (PCs) with mature-like morphology. (D) CD 138 immunostain shows strong membrane staining by sheets of PCs, representing 25/30% BM cells. (E, F) Immunostainining for light chains reveals monotypic cytoplasmic expression of lambda light chain, suggesting the neoplastic nature of PCs.

Reference

1. Montefusco E, Monarca B, Tribalto M. Coexistent idiopathic thrombocythaemia and monoclonal component: a causal association? Scand J Haematol. 1985; 35:584. PMID: 4089537.

2. Kyrtsonis MC, Kokoris SI, Kontopidou FN, Siakantaris MP, Kittas C, Pangalis GA. Development of a myeloproliferative disorder in a patient with monoclonal gammopathy of undetermined significance secreting immunoglobulin of the M class and treated with thalidomide and anti-CD20 monoclonal antibody. Blood. 2001; 97:2527–2528. PMID: 11307775.

3. Tosato F, Fossaluzza V, Rossi P, et al. Monoclonal gammopathy of undetermined significance in a case of primary thrombocythemia. Haematologica. 1986; 71:417–418. PMID: 3096839.

4. Prosper F, Borbolla JR, Rifon J, et al. Coexistence of essential thrombocythemia and multiple myeloma. Ann Hematol. 1992; 65:103–105. PMID: 1511057.

5. Majhail NS, Lichtin AE. Rare coexistence of multiple myeloma with essential thrombocythemia: report of two cases. Haematologica. 2003; 88:ECR09. PMID: 12681982.

6. Kuroda J, Matsumoto Y, Tanaka R, et al. JAK2V617F-positive essential thrombocythemia and multiple myeloma with IGH/CCND1 gene translocation coexist, but originate from separate clones. Acta Haematol. 2008; 120:177–181. PMID: 19129688.

7. Holtan SG, Hoyer JD, Buadi FK. Multiple myeloma with concomitant JAK2-positive essential thrombocythemia post-successful autologous peripheral blood hematopoietic stem cell transplant. Bone Marrow Transplant. 2011; 46:615. PMID: 20581888.

8. Eskazan AE, Ongoren S, Ar MC, et al. Essential thrombocythemia and multiple myeloma: two rare diseases in one patient. Clin Lymphoma Myeloma Leuk. 2011; 11:442–445. PMID: 21859555.

9. Dispenzieri A. How I treat POEMS syndrome. Blood. 2012; 119:5650–5658. PMID: 22547581.