J Rheum Dis.  2016 Apr;23(2):101-108. 10.4078/jrd.2016.23.2.101.

Factors Associated with Airway Disease and Interstitial Lung Disease in Rheumatoid Arthritis

• Kim JW
• Lee H
• Hwang JH
• Park SH
• Lee HS
• Kim SK
• Choe JY

• KMID: 2222786
• DOI: http://doi.org/10.4078/jrd.2016.23.2.101

Abstract

OBJECTIVE
This study examined lung involvement in patients with rheumatoid arthritis (RA) and identified factors associated with airway disease (AD) and interstitial lung disease (ILD).
METHODS
A total of 507 RA patients were enrolled in a cross-sectional study. Lung involvement was assessed by high-resolution computed tomography scan. The patient groups were classified according to normal, AD, and ILD. Multinomial logistic regression analysis was performed to identify factors associated with AD and ILD.
RESULTS
The most frequent lung involvement was AD (38.3%) followed by ILD (12.6%). Old age (adjust odds ratio [aOR] 2.58, 95% confidence interval [CI] 1.70 to 3.90 for AD; aOR 4.38, 95% CI 2.30 to 8.35 for ILD), male gender (aOR 2.57, 95% CI 1.22 to 5.42 for AD; aOR 5.48, 95% CI 2.20 to 13.65 for ILD) were factors associated with AD and ILD in RA patients. ILD was associated with short disease duration (aOR 0.30, 95% CI 0.14 to 0.62), AD was associated with high titers of anti-cyclic citrullinated peptides antibodies (anti-CCP; aOR 1.61, 95% CI 1.07 to 2.44).
CONCLUSION
AD was the most frequent lung involvement in patients with RA. Old age and male gender were both associated with AD and ILD. Short disease duration was associated with ILD. High titers of anti-CCP was associated with AD.

Keyword

Rheumatoid arthritis; Obstructive lung diseases; Interstitial lung diseases; X-ray computed tomography; Risk factors

MeSH Terms

Antibodies
Arthritis, Rheumatoid*
Cross-Sectional Studies
Humans
Logistic Models
Lung
Lung Diseases, Interstitial*
Lung Diseases, Obstructive
Male
Odds Ratio
Peptides
Risk Factors
Tomography, X-Ray Computed
Antibodies
Peptides

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