Korean J Med.  2016 Jun;90(6):487-493. 10.3904/kjm.2016.90.6.487.

Non-AIDS Morbidity among HIV Patients

• Kim SW

• KMID: 2218769
• DOI: http://doi.org/10.3904/kjm.2016.90.6.487

Abstract

Human immunodeficiency virus (HIV) infection and acquired immune deficiency syndrome (AIDS) have become a chronic condition rather than an acute life-threatening disease. Highly active antiretroviral treatment has dramatically increased the life expectancy of patients with HIV infection, who are now aging while receiving treatment. HIV patients are at higher risk for cardiovascular disease, diabetes, hypertension, bone disease, kidney disease, liver disease, psychiatric disease, and some non-AIDS-related cancers than patients in the general population. To avoid these non-AIDS morbidities, treating traditional age- and lifestyle-related conditions is important. Early treatment also reduces non-AIDS morbidity. Therefore, to reduce the risk for developing non-AIDS morbidity, it is crucial to start antiretroviral therapy (ART) early. Some ARTs are risk factors for the development of non-AIDS morbidities (e.g., nephrotoxicity with tenofovir). With the initial assessment and follow-up monitoring of non-AIDS morbidity, we have to consider switching ARTs to minimize adverse effects. Non-AIDS complications in HIV patients will become more important with advances in HIV therapy.

Keyword

HIV; Acquired immunodeficiency syndrome; Comorbidity; Antiretroviral therapy, Highly active; Aging

MeSH Terms

Acquired Immunodeficiency Syndrome
Aging
Antiretroviral Therapy, Highly Active
Bone Diseases
Cardiovascular Diseases
Comorbidity
Follow-Up Studies
HIV Infections
HIV*
Humans
Hypertension
Kidney Diseases
Life Expectancy
Liver Diseases
Risk Factors