Allergy Asthma Respir Dis.  2016 Jan;4(1):65-69. 10.4168/aard.2016.4.1.65.

Diffuse panbronchiolitis in an adolescent female

• Kim HY
• Son SK
• Park HJ

• KMID: 2218622
• DOI: http://doi.org/10.4168/aard.2016.4.1.65

Abstract

Diffuse panbronchiolitis (DPB) is a progressive inflammatory respiratory disease of unknown cause mainly occurring in East Asian people. Studies on causes of the disease point to a genetic predisposition unique to Asians, but the cause remains unknown. If untreated, DPB progresses to bronchiectasis, respiratory failure, and death. The age of patients at onset of the disease varies from young to elderly people with a peak at 40-60 years. A few cases of DPB have been reported in Korean adults since 1992; however, the case of DPB in children is uncommon. Herein, we describe a 16-year-old girl with DPB who presented with chronic cough and sputum.

Keyword

Diffuse panbronchiolitis; Child; Macrolides

MeSH Terms

Adolescent*
Adult
Aged
Asian Continental Ancestry Group
Bronchiectasis
Child
Cough
Female*
Genetic Predisposition to Disease
Humans
Macrolides
Respiratory Insufficiency
Sputum
Macrolides

Figure

• 

  Fig. 1 Serial change of chest x-ray (A) in 2009; 4 years before diagnosis (B) in 2013; at initial diagnosis (C) in 2014; before treatment (D) in 2015; a year after treatment.

• 

  Fig. 2 Chest computed tomography at initial diagnosis (A, B) and before treatment (C, D).

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