J Korean Ophthalmol Soc.  2009 Oct;50(10):1539-1547. 10.3341/jkos.2009.50.10.1539.

Comparison of Time Domain OCT and Spectrum Domain OCT for Retinal Nerve Fiber Layer Assessment

• Kim BK
• Lee DW
• Ahn M
• Cho NC

• KMID: 2212773
• DOI: http://doi.org/10.3341/jkos.2009.50.10.1539

Abstract

PURPOSE
To compare retinal nerve fiber layer (RNFL) thickness obtained with Stratus optical coherence tomography (OCT) and Cirrus OCT.
METHODS
Sixty-one normal eyes were evaluated with Stratus and Cirrus OCT on the same day, and the RNFL thicknesses measured by the two OCT machines were compared. The correlation between the two data sets was obtained using Pearson's correlation coefficient. The correlation between RNFL thickness and the difference in data measured by the two OCT machines was then assessed.
RESULTS
The average RNFL thickness was significantly higher with Stratus OCT by 6.54+/-4.48 micrometer (p=0.0008). A strong correlation was present between the two RNFL thickness data sets (r=0.883), and the difference between Stratus and Cirrus values tended to increase as RNFL thickness increased.
CONCLUSIONS
RNFL thickness measurements in normal eyes scanned with Cirrus OCT correlate well with Stratus OCT measurements. Average RNFL thickness was significantly higher with Stratus OCT, and as the RNFL thickness increased, the difference between Stratus and Cirrus values increased.

Keyword

Cirrus; Optical coherence tomography; Retinal nerve fiber layer thickness; Stratus

MeSH Terms

Eye
Nerve Fibers
Retinaldehyde
Tomography, Optical Coherence
Retinaldehyde

Figure

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  Figure 1. (A) Fundus photograph with white box indicating scanning area of Cirrus OCT, (B) Fundus photograph with the six radial line scanning pattern of Stratus OCT.

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  Figure 2. Scatter plots of the Stratus RNFL thickness versus the Cirrus RNFL thickness. (A) Mean RNFL thickness, (B) Temporal RNFL thickness, (C) Superior RNFL thickness, (D) Nasal RNFL thickness, (E) Inferior RNFL thickness.

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  Figure 3. Bland-Altman plots of Stratus minus Cirrus thickness differences versus the average RNFL. (A) Mean RNFL thickness, (B) Temporal RNFL thickness,(C) Superior RNFL thickness, (D) Nasal RNFL thickness,(E) Inferior RNFL thickness.

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  Figure 4. (A) Stratus OCT and Cirrus OCT RNFL profiles.(B) Stratus OCT scan. (C) Cirrus OCT scan. Red dashed lines indicate two places where the two scans differ the most. And red arrows indicate shadow of retinal blood vessels.

Reference

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