J Korean Ophthalmol Soc.  2018 Jun;59(6):537-542. 10.3341/jkos.2018.59.6.537.

Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography in Healthy Koreans

• Choi Y
• Cho BJ

• KMID: 2413816
• DOI: http://doi.org/10.3341/jkos.2018.59.6.537

Abstract

PURPOSE
To determine normal retinal nerve fiber layer (RNFL) thickness by age and to investigate the relationships of the RNFL with clinical variables using spectral domain optical coherence tomography (SD-OCT) in healthy Koreans.
METHODS
The peripapillary RNFL thicknesses were measured around the optic disc using consecutive circular B-scans with 3.5 mm diameter and automatically calculated using a SD-OCT.
RESULTS
Three hundreds fifty-two eyes of 205 healthy subjects were included in the study and RNFL thickness were measured by SD-OCT. Overall average RNFL thickness was 100.2 ± 10.9 µm, and significantly and negatively correlated with age (r = −0.164, p = 0.002). The overall average RNFL thickness decrease per decade was 0.8 µm (95% confidence interval, −0.3 to −1.3, p = 0.019). Mean RNFL thickness of each quadrant was significantly correlated with axial length except in the superior quadrant.
CONCLUSIONS
This study describes the normal RNFL thickness values of Koreans as determined by SD-OCT. Furthermore, age was found to be correlated with normal RNFL thickness, however age-related changes were not uniform across every region.

Keyword

Axial length; Cup-to-disc ratio; Korean; Retinal nerve fiber layer; Spectral domain optical coherence tomography

MeSH Terms

Clothing
Healthy Volunteers
Nerve Fibers*
Retinaldehyde*
Tomography, Optical Coherence*
Retinaldehyde

Figure

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  Figure 1. Associations between overall retinal nerve fiber layer (RNFL) thickness and age. Age significantly affected overall average RNFL thickness, and the rate of average RNFL thinning was approximately 0.8 μ m per decade. dots mean individual RNFL thickness for age, line mean RNFL thickness average.

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  Figure 2. The associations between retinal nerve fiber layer (RNFL) thickness and axial length (AXL). AXL significantly affected average RNFL thickness in four quadrants. RNFL thicknesses in superior, nasal, and inferior quadrants decreased and RNFL thickness in temporal quadrant increased as AXL increased. dots mean RNFL thickness for AXL, lines are pre-sented as mean RNFL thickness. T = temporal; S = superior; N = nasal; I = inferior.

Reference

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