J Periodontal Implant Sci.  2014 Aug;44(4):207-213. 10.5051/jpis.2014.44.4.207.

Micronutrients and superoxide dismutase in postmenopausal women with chronic periodontitis: a pilot interventional study

• Daiya S
• Sharma RK
• Tewari S
• Narula SC
• Kumar Sehgal P

• KMID: 2212015
• DOI: http://doi.org/10.5051/jpis.2014.44.4.207

Abstract

PURPOSE
The study was aimed at investigating changes in periodontal parameters and superoxide dismutase activity triggered by root surface debridement with and without micronutrient supplementation in postmenopausal women.
METHODS
Forty-three postmenopausal chronic periodontitis patients were divided into two groups: group 1 (n=22) were provided periodontal treatment in the form of scaling and root planing (SRP) and group 2 (n=21) patients received SRP along with systemic administration of micronutrient antioxidants. Patients in both groups were subjected to root surface debridement. Group 2 patients also received adjunctive micronutrient antioxidant supplementation. Serum and salivary superoxide dismutase (SOD) activity along with periodontal parameters were recorded at baseline and 3 months after therapy.
RESULTS
Salivary and serum SOD values significantly (P<0.05) improved with periodontal treatment. Improvement in systemic enzymatic antioxidant status along with reduction in gingival inflammation and bleeding on probing (%) sites was significantly greater in group 2 as compared to group 1.
CONCLUSIONS
Adjunctive micronutrient supplements reduce periodontal inflammation and improve the status of systemic enzymatic antioxidants in postmenopausal women.

Keyword

Antioxidants; Clinical trial; Chronic periodontitis; Root planning

MeSH Terms

Antioxidants
Chronic Periodontitis*
Debridement
Female
Hemorrhage
Humans
Inflammation
Micronutrients*
Root Planing
Superoxide Dismutase*
Antioxidants
Micronutrients
Superoxide Dismutase

Figure

• 

  Figure 1 Comparison of serum superoxide dismutase (SOD) activity (%) between groups 1 and 2 at baseline and follow-up values. Group 1: Patients who received scaling and root planning for the treatment of chronic periodontitis. Group 2: Patients who received scaling and root planning along with micronutrient supplementation. SD: standard deviation. **Statistical significance with Wilcoxon signed-rank test is P<0.01.

• 

  Figure 2 Comparison of salivary superoxide dismutase (SOD) activity (%) between groups 1 and 2 at baseline and follow-up values. Group 1: Patients who received scaling and root planning for the treatment of chronic periodontitis. Group 2: Patients who received scaling and root planning along with micronutrient supplementation. SD: standard deviation. ***Statistical significance with Wilcoxon signed-rank test is P<0.001.

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