J Menopausal Med.  2021 Dec;27(3):155-161. 10.6118/jmm.20035.

Assessment of Psychological Status and Oxidative Stress in Postmenopausal Women: A Cross-Sectional Study

• Chandankhede M
• Gupta M
• Pakhmode S

• KMID: 2523750
• DOI: http://doi.org/10.6118/jmm.20035

Abstract

Objectives
During menopause, women may experience some physical changes that can affect their psychological status. Oxidative stress also increases with menopause, as decreasing levels of estrogen reinforce the deterioration of antioxidant status. To assess total antioxidative capacity, malondialdehyde, superoxide dismutase, and glutathione peroxidase and the correlation between psychological status and oxidative stress in postmenopausal women.
Methods
This cross-sectional study was undertaken on 100 postmenopausal women (40–59 years). Blood malondialdehyde, superoxide dismutase, glutathione peroxidase, and total antioxidative capacity were analyzed, and psychological status was assessed using Rosenberg’s self-esteem test, Zung’s self-rating anxiety scale, and Zung’s self-rating depression scale.
Results
Of the women, 38.0% had mild to moderate symptoms of anxiety (mean ± standard deviation, 50.15 ± 4.89), 21.0% showed depression, and 19.0% had low self-esteem. Twelve percent of the study population had mild to moderate symptoms of all three disorders. A statistically significant difference was found in the scores of anxiety and self-esteem (P = 0.001 and P < 0.001 in women with and without psychological disturbances, respectively). With regard to oxidative stress parameters, only superoxide dismutase levels showed a statistically significant difference (P = 0.001), with lower levels found in women with psychological disturbance.
Conclusions
Women with depression, anxiety, and low self-esteem are in an oxidative challenge, which might be associated with estrogen depletion. A lower superoxide dismutase level is associated with higher depression and anxiety scores in postmenopausal women.

Keyword

Antioxidant activity; Anxiety; Depression; Superoxide dismutase; Postmenopause