J Korean Ophthalmol Soc.  2009 Jan;50(1):105-112. 10.3341/jkos.2009.50.1.105.

The Relationship Between Intraocular Pressure and Health Parameters

• Lee JK
• Lee JS
• Kim YK

• KMID: 2211904
• DOI: http://doi.org/10.3341/jkos.2009.50.1.105

Abstract

PURPOSE
This study analyzed the relationship between intraocular pressure (IOP) and health parameters, including waist circumference, in healthy Koreans.
METHODS
A total of 6169 healthy participants underwent automated multi-phasic tests including tonometry, automated perimetry, and fundus photography. Parameters of these patients including height, weight, degree of obesity, body fat percentage, waist circumference, body mass index, and body muscle rate, were recorded. The subjects were divided into six age groups by decades ranging from 20~29 years to over 70 years. Multiple regression analysis was used to examine the relationship between IOP and the parameters mentioned above.
RESULTS
The mean age of the participants was 47.87 years, and 3015 (51.1%) of the participants were men. The mean IOP was 13.58+/-3.1 mmHg, and was significantly higher in men than in women (p<0.05). The prevalence of ocular hypertension was 2.0% in men and 2.2% in women. IOP was associated with gender, age, height, weight, degree of obesity, body fat percentage, waist circumference, and body mass index (p<0.05). The relation between IOP and age showed a significantly negative tendency (p<0.05). Height, weight, degree of obesity, body fat percentage, waist circumference, and body mass index had a significantly positive relation with IOP (p<0.05). There was no significant relation between IOP and body muscle percentage (p>0.05).
CONCLUSIONS
Because increased IOP is associated with several health parameters that can be modified by diet and exercise such as weight, body fat percentage, body mass index, and waist circumference, it is recommended that these be reduced.

Keyword

Glaucoma; Health Parameters; Intraocular Pressure

MeSH Terms

Adipose Tissue
Body Mass Index
Body Weight
Diet
Female
Glaucoma
Humans
Intraocular Pressure
Male
Manometry
Muscles
Obesity
Ocular Hypertension
Photography
Prevalence
Visual Field Tests
Waist Circumference

Reference

References

1. Meckenzie W. Practical treatise on the disease of the eye. 2nd. London: Longman;1835. p. 822.

2. Jung SK, Lee SK, Kim JH. Intraocular pressure change by the hemodialysis. J Korean Ophthalmol Soc. 1995; 36:2195–201.

3. Drance S, Sweeney U, Morgan R. Studies of factors involved in the production of low-tension glaucoma. Arch Ophthalmol. 1973; 89:457–65.

4. Gasser P. Ocular vasospasm: A risk factor in the pathogenesis of low tension glaucoma. Int Ophthalmol. 1989; 13:281–90.

5. Rojanapongpun P, Drance SM. The response of blood flow velocity in the ophthalmic artery and cold stimuli in glaucomatous patients. Graefe Arch Clin Ophthalmol. 1993; 231:375–7.

6. Demailly P, Cambien F, Plouin PF. Do patient with low tension glaucoma have particular cardiovascular characteristics? Ophthalmologica. 1984; 188:65–75.

7. Kaiser HJ, Flammer J. Systemic hypotension: a risk factor for glaucomatous damage? Ophthalmologica. 1991; 203:105–8.

8. Hollows FC, Graham PA. Intraocular pressure, glaucoma and glaucoma suspects in a defined population. Br J Ophthalmol. 1966; 50:570–86.

9. Carel RS, Korczyn AD, Rock M, Goya I. Association between ocular pressure and certain health parameters. Ophthalmology. 1984; 91:311–4.

10. Schulzer M, Drance SM. Intraocular pressure, systemic blood pressure, and age: a correlation study. Br J Ophthalmol. 1987; 71:245–9.

11. Kahn HA, Leibowwitz HM, Ganly JP. . The Framlingham Eye Study: 2. Association of ophthalmic pathology with single variables previously measured in Framlingham Heart Study. Am J Epidemiol. 1977; 106:33–41.

12. Shiose Y, Kawase Y. A new approach to stratified normal intraocular pressure in a general population. Am J Ophthalmol. 1986; 101:714–21.

13. Shiose Y. The aging effect on intraocular pressure in an apparently normal population. Arch Ophthalmol. 1984; 102:883–7.

14. Qureshi IA. Intraocular pressure: a comparative analysis in two sexes. Clin Physiol. 1997; 17:247–55.

15. Nomura H, Shimokata H, Ando F. . Age-related changes in intraocular pressure in a large Japanese population. Ophthalmology. 1999; 106:2016–22.

16. Leske MC, Connell AM, Wu SY. . Distribution of intraocular pressure: the Barbados Eye Study. Arch Ophthalmol. 1997; 115:1051–7.

17. Mori K, Ando F, Nomura H. . Relationship between intraocular pressure and obesity in Japan. Int J Epidimiol. 2000; 29:661–6.

18. Lee JS, Kim CM, Choi HY, Oum BS. A relationship between Intraocular pressure and Age and Body Mass Index in a Korean Population. J Korean Ophthalmol Soc. 2003; 44:1559–66.

19. Kwon GR, Kang SW, Kee CW. The Influence of Central Corneal Thickness on Intraocular Pressures Measured with Goldmann Applanation Tonometer and Non-contact Tonometer. J Korean Ophthalmol Soc. 1998; 39:1494–8.

20. Bae GJ, Han TW, Ahn MD, Kim JH. Comparison of the Noncontact Tonometer with Goldmann Tonometer. J Korean Ophthalmol Soc. 1992; 33:642–8.

21. Kass MA, Zimmerman TJ, Alton E. . Intraocular pressure and glaucoma in the Zuni Indians. Arch Ophthalmol. 1978; 96:2212–3.

22. Klein BE, Klein R, Linton KL. Intraocular pressure in an American community. The Beave Dam Eye study. Invest Ophthalmol Vis Sci. 1992; 33:2224–8.

23. Stoupel E, Goldenfeld M, Shimshoni M, Siegel R. Intraocular pressure in relation to four levels of daily geomagnetic and extreme yearly solar activity. Int J Biometeorol. 1993; 37:42–5.

24. Bulpitt CJ, Hodes C, Everott MG. Intraocular pressure and systemic blood pressure in the elderly. Br J Ophthalmol. 1975; 59:717–20.

25. Kass MA, Sears ML. Hormonal regulation of intraocular pressure. Surv Ophthalmol. 1977; 22:153–76.

26. Matsuki S, Suzuki A. Definition, judgement and epidemiology of obesity. Clin Adult Dis. 1979; 9:919–23.

27. Jung SC, Choi YR, Lee JS. The Relationship between Intraocular Pressure and Cardiovascular Risk Factors. J Korean Ophthalmol Soc. 2003; 44:1559–66.

28. Katavisto M, Sammalkivi J. Tonometry among persons over 40 years of age. Acta Ophthalmol Scand. 1964; 42:370–7.

29. Perry AC, Applegate EB, Allison ML. . Relation between anthropometric measures of fat distribution and cardiovascular risk factors in overweight pre- and postmenopausal women. Am J Clin Nutr. 1997; 66:829–36.

30. Seidell JC, Han TS, Feskens EJ, Lean ME. Narrow hips and broad waist circumference independently contribute to increased risk of noninsulin-dependent diabetes mellitus. J Intern Med. 1997; 242:401–6.

31. Han TS, Bijnen FC, Lean ME, Seidell JC. Separate associations of waist and hip circumference with lifestyle factors. Int J Epidemiol. 1998; 27:422–30.

32. Fujioka S, Matsuzawa Y, Tokunaga K, Tauri S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. Metabolism. 1987; 36:54–9.

33. Kwon OH, Lee KM, No TM. . Cardiovascular risk factors in men with normal and overweight according to waist- to-height ratio. J Korean Acad Fam Med. 2001; 22:1757–64.