J Korean Surg Soc.
2000 Jan;58(1):109-114.
Chemoembolization in the Treatment of Multiple or Unresectable Hepatic Metastases from Colorectal Cancer
- Affiliations
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- 1Department of Surgery, Ewha Womans University, Medical School.
- 2Department of Radiology, Ewha Womans University, Medical School.
Abstract
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BACKGROUND: Hepatic artery chemoembolization represents an alternative treatment for patients of
metastasis or primary hepatic malignant lesions. The aims of this study was confirm the usefulness, the
complications and the survival benefits of chemoembolization for patients with colorectal carcinoma
metastasis to the liver.
METHODS
During 3 years, 23 patients with multiple or bulky unresectable liver metastasis from colorectal cancer were treated with chemoembolization using adriamycin, cisplatin or mitomycin with lipiodol . Repeated treatments were perform at 6- to 8-week intervals.
RESULTS
Hepatic metastases were detected at the initial diagnosis of colorectal cancer in 15 patients. The metastatic lesions included 7 cases of a single bulky lesion and 16 cases of multiple lesions. A decrease of at least 25% of the baseline CEA level occurred transiently in 43% of the cases. The median survival for all 23 patients was 10 months after initiation of chemoembolization, and the 1-year survival rate was 36%. Complications were liver abscesses with cholecystitis, thrombocytopenia, and ascites.
CONCLUSION
Chemoembolization is feasible treatment modality for patients with multiple or un resectable hepatic metastases from colorectal cancer.
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