J Korean Ophthalmol Soc.  2005 Aug;46(8):1321-1327.

Effect of Photodynamic Therapy and Intravitreal Triamcinolone Acetonide on Choroidal Neovascularization in Age-related Macular Degeneration

• Oh HS
• Roh MI
• Oh SJ
• Lee SC
• Lee WY
• Kwon OW

Abstract

PURPOSE
To evaluate the safety and visual outcome of intravitreal triamcinolone acetonide combined with photodynamic therapy for subfoveal choroidal neovascularization in patients with age-related macular degeneration. METHODS: We evaluated 32 eyes of 32 patients with choroidal neovascularization due to age-related macular degeneration. The study group received photodynamic therapy and intravitreal triamcinolone acetonide (combined group), while the control group received photodynamic therapy only (PDT group). RESULTS: Three months after treatment, no difference was detected between the two groups in visual acuity changes (p>0.05), but the leakage in fluorescein angiography and macular edema in optical coherent tomography decreased (p<0.05) in the combined group. The retreatment rate in the combined group (6.0%) after 3 months was lower than that of the PDT group (53.3%). CONCLUSIONS: Photodynamic therapy with intravitreal triamcinolone acetonide to choroidal neovascularization reduced the retreatment rate at 3 months significantly. These results may have been be due to the short-term anti-inflammatory effect of steroids.

Keyword

Age-related macular degeneration; Choroidal neovascularization; Intravitreal triamcinolone acetonide; Photodynamic therapy

MeSH Terms

Choroid*
Choroidal Neovascularization*
Fluorescein Angiography
Humans
Macular Degeneration*
Macular Edema
Photochemotherapy*
Retreatment
Steroids
Triamcinolone Acetonide*
Triamcinolone*
Visual Acuity
Steroids
Triamcinolone
Triamcinolone Acetonide