J Korean Soc Magn Reson Med.  2000 Jun;4(1):52-57.

Disturbed Functional Asymmetry of Sensorimotor Cortex in Schizophrenia: A Study with Functional Magnetic Resonance Imaging

• Ahn KJ
• Chae JH
• Kim T
• Kim EN
• Lee JM
• Choi KH
• Hahn ST

Abstract

PURPOSE
The purpose of this study was to investigate the pattern of cerebral response to motor tasks in patients with schizophrenia compared with normal subjects using functional MRI.
MATERIALS AND METHODS
Nine right handed-schizophrenic patients and six right-handed normal subjects were included. We used right hand movement as task. Series of 120 consecutive echo-planar images per section were acquired during three cycles of task and rest activations. Lateralization index of cortical response was measured and compared between patients and normal subjects.
RESULTS
Right hand motor task was associated with greater activation in left sensorimotor cortex than the right in normal subjects. Schizophrenia patients showed relatively decreased activation in left cortex and increased activation in right cortex compared with normal subjects. In one patient, reversed lateralization was noted.
CONCLUSION
Normal hemispheric asymmetry of cortical response to motor task was found in different pattern in schizophrenia. Our result is consistent with functional disturbance of motor circuitry in this disorder. Functional MRI will play an important role in diagnosis and research of this disorder.

Keyword

brain; functional MRI; motor; schizophrenia

MeSH Terms

Brain
Diagnosis
Hand
Humans
Magnetic Resonance Imaging*
Schizophrenia*