J Korean Surg Soc.  1999 Aug;57(2):180-188.

Significance of PCNA Oncoprotein as a Prognostic Predictor for Human Breast Cancer

• Kim HJ
• Cho SH
• Kim MC
• Kim YH
• Jung GJ
• Kim SS
• Hong SH

Abstract

BACKGROUND: Many studies of PCNA (proliferating cell nuclear antigen) as a prognostic factor of breast cancer have been done recently. The aim of this study was to evaluate the relation between expression of PCNA and poor prognosis for a patient with breast cancer.
METHODS
Immunohistochemical staining for PCNA was performed on sections from paraffin- embedded tissue blocks of 96 primary breast-cancer patients who were operated on at our hospital. We investigated the correlation between the traditional prognostic factors (patient age, primary tumor size, axillary lymph-node metastasis, pathological grade, and hormonal receptors) and PCNA expression.
RESULTS
Statistically, the PCNA expression was not correlated with patient age, primary tumor size, menopausal state, pathologic grade, axillary lymph-node metastasis, or hormonal receptor (P>0.05). Thus a correlation between expression of PCNA and poor prognosis for breast cancer was not found in this study.
CONCLUSIONS
More research using other monoclonal antibodies is needed to evaluate the relationship between expression of PCNA and the prognosis for breast cancer.

Keyword

Proliferating cell nuclear antigen; Breast cancer

MeSH Terms

Antibodies, Monoclonal
Breast Neoplasms*
Breast*
Humans*
Neoplasm Metastasis
Prognosis
Proliferating Cell Nuclear Antigen*
Antibodies, Monoclonal
Proliferating Cell Nuclear Antigen