J Korean Breast Cancer Soc.  1998 Jun;1(1):69-78. 10.4048/jkbcs.1998.1.1.69.

The Significance of C-erbB-2 Oncoprotein Expression as a Prognostic Predictor in Human Breast Cancer

• Park KJ
• Cho SH
• Kim YH
• Jung GJ
• Kim SS
• Hong SH

• KMID: 2173697
• DOI: http://doi.org/10.4048/jkbcs.1998.1.1.69

Abstract

The immunohistochemical staining for the C-erbB-2 oncoprotein was performed on sections from paraffin embedded tissue blocks of 96 primary breast cancer patient who underwent operation in our hospital. in order to evaluate the significances as a prognostic factor in the human breast cancer. We investigated the correlation between traditional prognostic factors-patient age, primary tumor size, axillary lymph node metastasis, pathological grade, hormonal receptors (ER &PR)-and C-erbB-2 oncoprotein overexpression. The overall rates of positive staining of C-erbB-2 oncoprotein was 37.5% (36/96). Statistically, the C-erbB-2 positive staining was not correlated with patient age, primary tumor size, axillary lymph node involvement, hormonal receptors, But the high pathologic grade was correlated with C-erbB-2 oncoprotein overexpression and appeared statistically significant (p=0.010). The C-erbB-2 oncoprotein appeared to have prognostic significance in human breast cancer the result.

Keyword

C-erbB-2; Breast Cancer

MeSH Terms

Breast Neoplasms*
Breast*
Humans*
Lymph Nodes
Neoplasm Metastasis
Paraffin
Paraffin