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Clinical Significance and Characteristics of Newly Detected Lesions on Breast MRI During Neoadjuvant Chemotherapy

Lee K, Nam KJ, Choo KS, Nam SB, Kim HY, Jung YJ, Kim JJ, Joo JH, Kim JY, Lee JW, Hwang JY, Park C

Purpose This study aimed to evaluate clinical significance and imaging findings of newly detected lesions on breast MRI while monitoring patients’ response to neoadjuvant chemotherapy (NAC). Materials and Methods We identified 291 patients...
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Journey to hypofractionation in radiotherapy for breast cancer: critical reviews for recent updates

Kim N, Kim YB

Historical conventional fractionated radiation therapy (RT) for breast cancer consisted of 1.8–2.0 Gy per fraction with a total dose of 45–60 Gy over 5–7 weeks. Based on radiobiological characteristics, a...
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Use of Artificial Intelligence for Reducing Unnecessary Recalls at Screening Mammography: A Simulation Study

Kim YS, Jang Mj, Lee SH, Kim SY, Ha SM, Kwon BR, Moon WK, Chang JM

Objective: To conduct a simulation study to determine whether artificial intelligence (AI)-aided mammography reading can reduce unnecessary recalls while maintaining cancer detection ability in women recalled after mammography screening. Materials and...
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Effect of equipotent doses of propofol and sevoflurane on endoplasmic reticulum stress during breast cancer surgery

Oh CS, Hong SW, Park S, Kwon Y, Kim SH

Background: Numerous studies suggest that intravenous propofol is superior to inhaled volatile anesthetic. This study compared the changes in the endoplasmic reticulum (ER) stress of cancer cells and lymphocytes after...
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Risk of Breast Cancer in Association with the Use of Second-generation Antipsychotics

Joo SW, Lee BC, Lee J, Seo GH

Objective: Previous studies regarding the relationship between the risk of breast cancer (BC) and antipsychotics use have reported inconsistent findings. Insufficient sample size and/or observation period may have hindered revealing...
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The Effect of Temperament on the Association Between Pre-treatment Anxiety and Chemotherapy-Related Symptoms in Patients With Breast Cancer

Choi JI, Jung S, Oh GH, Son KL, Lee KM, Jung D, Kim TY, Im SA, Lee KH, Shin MS, Hahm BJ, Yeom CW

Objective Pre-treatment anxiety (PA) before chemotherapy increases complaints of chemotherapy-related symptoms (CRS). The results on the association have been inconsistent, and the effect of temperament remains unclear. We aimed to...
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Hydroxyzine Induces Cell Death in Triple-Negative Breast Cancer Cells via Mitochondrial Superoxide and Modulation of Jak2/STAT3 Signaling

Shakya R, Park GH, Joo SH, Shim JH, Choi JS

Treatment of triple-negative breast cancer (TNBC) has been limited due to the lack of molecular targets. In this study, we evaluated the cytotoxicity of hydroxyzine, a histamine H1 receptor antagonist...
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Digital Breast Tomosynthesis versus MRI as an Adjunct to Full-Field Digital Mammography for Preoperative Evaluation of Breast Cancer according to Mammographic Density

Kim H, Yang SY, Ahn JH, Ko EY, Ko ES, Han BK, Choi JS

Objective: To compare digital breast tomosynthesis (DBT) and MRI as an adjunct to full-field digital mammography (FFDM) for the preoperative evaluation of women with breast cancer based on mammographic density. Materials...
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Imaging Findings of Metaplastic Breast Carcinoma with Chondroid Differentiation: A Case Reports

Kim JY, Kim SH, Jeong MJ, Lee JH, Kang MJ, Gwak G, Yoo SH

Metaplastic carcinoma of the breast is a heterogeneous group of neoplasms with mixed epithelial and mesenchymal differentiation. Metaplastic carcinoma of the breast is a rare and aggressive malignancy, with high...
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Real-World Evidence of Trastuzumab, Pertuzumab, and Docetaxel Combination as a First-Line Treatment for Korean Patients with HER2-Positive Metastatic Breast Cancer

Lee YP, Lee MS, Kim H, Kim JY, Ahn JS, Im YH, Park YH

Purpose Trastuzumab has markedly improved the survival outcomes of patients with human epidermal growth factor receptor 2 (HER2)–positive breast cancer, and dual blockade of HER2 using trastuzumab and pertuzumab in...
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Real World Evidence of Neoadjuvant Docetaxel/Carboplatin/Trastuzumab/Pertuzumab (TCHP) in Patients with HER2-Positive Early or Locally Advanced Breast Cancer: A Single-Institutional Clinical Experience

Kim JY, Nam SJ, Lee JE, Yu J, Chae BJ, Lee SK, Ryu JM, Ahn JS, Im YH, Kim SW, Park YH

Purpose Docetaxel/carboplatin/trastuzumab/pertuzumab (TCHP) regimen is frequently used to treat early and locally advanced human epidermal growth factor receptor 2 (HER2)–positive breast cancer (BC) in neoadjuvant setting. However, large-scaled real-world evidence...
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Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors

Tran TXM, Jung SY, Lee EG, Cho H, Kim NY, Shim S, Kim HY, Kang D, Cho J, Lee E, Chang YJ, Cho H

Purpose Fear of cancer recurrence (FCR) is a common psychological issue in breast cancer (BC) survivors during early survivorship but whether the same is true among long-term survivors has yet...
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The effect of a support program on the burden of spouses caring for their partners with breast cancer: a randomized controlled trial

Hosseinnejad SZ, Elyasi F, Mousavinasab SN, Shahhosseini Z

Objective This study aimed to determine the effect of a support program on burden of spouses caring for their partners with breast cancer. Methods This randomized controlled trial was conducted among spouses of...
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A Case of Stewart-Treves Syndrome Derived from Lymphedema Lasting for about 20 Years

Kwon HJ, Yoo DW, Park KD, Kim KH, Yoon JH

  • KMID: 2532851
  • Korean J Dermatol.
  • 2022 Aug;60(7):453-454.
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Hormone Therapy and Risk of Breast Cancer: Where Are We Now?

Micha JP, Rettenmaier MA, Bohart RD, Goldstein BH

Several studies have examined the clinical benefits of hormone replacement therapy (HRT). However, because long-term use of HRT has been implicated as a risk factor for the development of breast...
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PRR16/Largen Induces Epithelial-Mesenchymal Transition through the Interaction with ABI2 Leading to the Activation of ABL1 Kinase

Kang GJ, Park JH, Kim HJ, Kim EJ, Kim B, Byun HJ, Yu L, Nguyen TM, Nguyen TH, Kim KS, Huy HP, Rahman M, Kim YH, Jang JY, Park MK, Lee H, Choi CI, Lee K, Han HK, Cho J, Rho SB, Lee CH

Advanced or metastatic breast cancer affects multiple organs and is a leading cause of cancer-related death. Cancer metastasis is associated with epithelial-mesenchymal metastasis (EMT). However, the specific signals that induce...
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Clinicopathological Characterization of Double Heterozygosity for BRCA1 and BRCA2 Variants in Korean Breast Cancer Patients

Bang YJ, Kwon WK, Nam SJ, Kim SW, Chae BJ, Lee SK, Ryu JM, Kim JW, Yu J, Lee JE

Purpose Double heterozygosity (DH) for BRCA1 and BRCA2 variant is very rare with only a few cases reported, and most those in Caucasians. In this article, we present seven unrelated...
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MRI Features for Prediction Malignant Intra-Mammary Lymph Nodes: Correlations with Mammography and Ultrasound

Kim M, Kang BJ, Park GE

Purpose: To assess clinically significant imaging findings of malignant intramammary lymph nodes (IMLNs) in breast cancer patients and to evaluate their diagnostic performance in predicting malignant IMLN. Materials and Methods: A...
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Breast Cancer Selective Disruption of Actin Cytoskeleton by Diallyl Trisulfide

Hahm ER, Mathan SV, Singh RP, Singh SV

Diallyl trisulfide (DATS) is an attractive anti-cancer phytochemical with in vitro and in vivo growth inhibitory effects against different solid tumors including breast cancer. We have shown previously that an...
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Accelerated hypofractionated breast radiotherapy with simultaneous integrated boost: a feasibility study

Yadav BS, Gupta S, Dahiya D, Gupta A, Oinam AS

Purpose: To assess the feasibility of accelerated hypofractionated radiotherapy with simultaneous integrated boost (SIB) in patients with breast cancer. Materials and Methods: A total of 27 patients after breast-conserving surgery were...
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