J Korean Ophthalmol Soc.
2000 Feb;41(2):392-399.
Apoptosis in Experimental Autoimmune Uveitis
- Affiliations
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- 1Department of Ophthalmology, College of Medicine, Seoul National University.
- 2Department of Ophthalmology, Inje University Sanggye Paik Hospital, Seoul, Korea.
- 3College of Medicine, Seoul National University.
Abstract
- Experimental melanin-induced uveitis[EMIU]was induced in Lewis rats to investigate the mechanisms of the tissue destruction and spontaneous turning off of the endogenous uveitis. The eyes were enucleated serially, and immunohistochemistry, TUNEL stains, and flow cytometry were performed. The major infiltrating inflammatory cells were CD4 T cells in the uveal tissue of EMIU. Apoptosis of these cells has occurred and progressed throughout the inflammatory period in EMIU eyes. Most TUNEL positive cells revealed CD4 positive. These results suggest that apoptotic cell death occurred primarily in the infiltrating inflammatory cells not in the tissue cells of the eye and the apoptosis of CD4 T cells may play a key role in the spontaneous turning off mechanism of intraocular inflammation in EMIU.
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