J Korean Ophthalmol Soc.  1999 Dec;40(12):3384-3389.

The Study of Intraocular Vascular Endothelial Growth Factor Concentration in Diabetic Retinopathy after Panretinal Photocoagulation

• Kim SD
• Kim JM
• Lee DP

Abstract

Vascular endothelial growth factor[VEGF] might play important roles in angiogenesis of diabetic retinopathy. Aim of this study is to determine the effect of panretinal photocoagulation[PRP] on the level of VEGF in intraocular fluid of proliferative diabetic retinopathy[PDR]. Aqueous humor was obtained during cataract surgery from 35 eyes of 35 patients with PDR and VEGF concentration was measured using enzyme-linked immunosorbent assay[ELISA]. Patients were classified into 4 groups according to total amount of panretinal photocoagulation[PRP][group A:no PRP, group B: less than 1000 spots, group C: 1000~1500 spots, group D: more than 1500 spots] and VEGF level was analyzed in each group using Spearman's correlation coefficient by rank. Mean concentration of VEGF is 615pg/mlin group A, 307pg/mlin group B, 234 pg/mlin group C, and 136pg/mlin group D. The level of VEGF was significantly lower as total amount of PRP increased[p<0.05]. These findings suggest that therapeutic effect of PRP on PDR can be explained by the reduction of VEGF concentration in intraocular fluid.

Keyword

Proliferative diabetic retinopathy; Panretinal photocoagulation; Vascular endothelial growth factor

MeSH Terms

Aqueous Humor
Cataract
Diabetic Retinopathy*
Humans
Light Coagulation*
Vascular Endothelial Growth Factor A*
Vascular Endothelial Growth Factor A