J Korean Ophthalmol Soc.  2016 Jun;57(6):917-923. 10.3341/jkos.2016.57.6.917.

Retinal Vascular Caliber Changes in Diabetic Retinopathy after Panretinal Photocoagulation and Additive Bevacizumab Injections

• Chey JH
• Park JM

• KMID: 2290493
• DOI: http://doi.org/10.3341/jkos.2016.57.6.917

Abstract

PURPOSE
To evaluate the effect of panretinal photocoagulation and additive intravitreal bevacizumab injections on central retinal vessel diameters and characteristic retinal vascular caliber changes in diabetic retinopathy.
METHODS
Changes in central retinal vessel diameters were retrospectively analyzed before and 6 months after panretinal photocoagulation with or without additive intravitreal bevacizumab injections in 64 eyes first diagnosed with diabetic retinopathy. Vessel diameters and arteriovenous ratio (AVR) were measured using Interactive Vessel Analysis (IVAN) software and the Big six formula.
RESULTS
There were significant decreases in central retinal artery equivalent (CRAE) and central retinal vein equivalent (CRVE) in both groups, with and without additive intravitreal bevacizumab injections, 6 months after completion of panretinal photocoagulation (p < 0.001, p = 0.008), but no significant change in AVR (p = 0.338). Additive intravitreal bevacizumab injections did not produce significant changes in central retinal vessel diameters after 6 months compared to vessel diameters treated with panretinal photocoagulation only. Retinal vascular caliber of progressed diabetic retinopathy showed smaller CRAE, larger CRVE, and smaller AVR compared to those of normal or diabetic Korean subjects in a previous study and showed no significant association with age.
CONCLUSIONS
CRAE and CRVE decreased significantly 6 months after panretinal photocoagulation in diabetic retinopathy, but additive intravitreal bevacizumab injections did not cause significant additive changes to central retinal vascular calibers in this study. We established the standard retinal vascular caliber of Korean subjects in diabetic retinopathy and analyzed the effects of retinopathy on retinal vessel caliber.

Keyword

Bevacizumab; Diabetic retinopathy; Panretinal photocoagulation; Retinal vascular caliber

MeSH Terms

Bevacizumab*
Diabetic Retinopathy*
Light Coagulation*
Retinal Artery
Retinal Vein
Retinal Vessels
Retinaldehyde*
Retrospective Studies
Bevacizumab
Retinaldehyde

Reference

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