J Korean Soc Clin Toxicol.  2008 Jun;6(1):52-56.

A Case of Amitraz Insecticide Intoxication after Ingestion of Large Amount

• Suh JH
• Roh HK

Abstract

Amitraz is used as farm-animal insecticide. Its side effects in humans are related to its pharmacological activity on alpha 2-adrenergic receptors. The case describes a previously healthy 46-year-old woman who intentionally ingested approximately 250mL of liquid amitraz. She presented with vomiting, altered mental status, miosis, dry mouth, hypopnea, metabolic and respiratory acidosis, hypotension, hypothermia, polyuria, metabolic acidosis, elevated serum aminotransferase and abdominal distension. Supportive treatments including mechanical ventilation, hydration, dopamine infusion, bicarbonate infusion and gastric decompression resulted in improvement. By hospital day 3, she recovered with resolution of abdominal distension. It is paramount to recognize amitraz poisoning when apesticide-intoxicated patient presets with signs and symptoms consistent with organophosphate intoxicated patients but with greater alpha 2-adrenergic related symptoms such as decreased bowel motility and xerostomia.

Keyword

Amitraz; Intoxication; Alpha-2-adrenergic agonist

MeSH Terms

Acidosis
Acidosis, Respiratory
Decompression
Dopamine
Eating
Female
Humans
Hypotension
Hypothermia
Intention
Middle Aged
Miosis
Mouth
Polyuria
Respiration, Artificial
Toluidines
Vomiting
Xerostomia
Dopamine
Toluidines