J Korean Rheum Assoc.  1995 Jul;2(2):207-211.

A Case of Chorea Associated with Antipholipid Antibodies in Patients with Systemic Lupus Erythematosus

• Cho YS
• Choi BS
• Yoh KA
• Yang HI
• Park SH
• Lee SH
• Cho CS
• Kim HY

Abstract

The neuropsychiatric manifestations of systemic lupus erythematosus (SLE) are diverse but, among them, movement disorders such as chorea, ataxia are uncommon. We describe a 16 year old female SLE patient with positive anticardiolipin antibody who developed sudden onset of chorea. The clinical and laboratory findings that positive anticardiolipin antibody, thrombocytopenia, chorea were suggested antiphospholipid syndrome. Although the pathophysiology of chorea in SLE is unknown, an association with. antiphospholipid antibodies has been suggested. The underlying pathogenic mechanism of this case could not established but was most likely to have been an ischemia of the contralateral subthalamic nucleus. She was treated with corticosteroid, haloperidol and warfarin and now chorea is disappered.

Keyword

Systemic lupus erythematosus; Chorea; Antiphosphplipid antibodies

MeSH Terms

Adolescent
Antibodies*
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Antiphospholipid Syndrome
Ataxia
Chorea*
Female
Haloperidol
Humans
Ischemia
Lupus Erythematosus, Systemic*
Movement Disorders
Subthalamic Nucleus
Thrombocytopenia
Warfarin
Antibodies
Antibodies, Anticardiolipin
Antibodies, Antiphospholipid
Haloperidol
Warfarin