Korean J Nucl Med.
2003 Oct;37(5):325-330.
Chorea in Systemic Lupus Erythematosus: Evidence for Bilateral Putaminal Hypermetabolism on F-18 FDG PET
- Affiliations
-
- 1Department of Internal Medicine, Universitiy of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. byoo@amc.seoul.kr
- 2Department of Nuclear Medicine, Universitiy of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
- 3Department of Neurology, Universitiy of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- PURPOSE
We describe a 54-year-old woman with systemic lupus erythematosus (SLE) who suddenly presented with chorea and had positive antiphospholipid antibodies. F-18 FDG PET showed abnormally increased glucose metabolism in bilateral putamen and primary motor cotex. Tc-99m ECD SPECT also showed abnormally increased regional cerebral blood flow in bilateral putamen. She was treated with corticosteroid and aspirin after which the symptoms improved. Four months later, follow up F-18 FDG PET showed improvement with resolution of hypermetabolism in bilateral putamen. This case suggests that striatal hypermetabolism is associated with chorea in SLE.