J Korean Neurol Assoc.  2004 Jun;22(3):255-258.

A Case of Systemic Lupus Erythematosus Presenting with Chorea: Evidence for Striatal Hypermetabolism

Affiliations
  • 1Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jhim@amc.seoul.kr
  • 2Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.

Abstract

Chorea is an uncommon clinical manifestation of Sytemic lupus erythematosus (SLE). Its pathogenic mechanism has not been clearly clarified. We report a 54-year-old woman with SLE who presented with generalized chorea as an initial manifestation. Fluorine-18-fluorodeoxyglucose (FDG) PET revealed increased metabolism in the bilateral putamen. Intravenous and oral administration of steroid markedly improved chorea. Hypermetabolism of the bilateral putamen diminished on follow-up FDG-PET after the disappearance of chorea. This study suggests that chorea in SLE is associated with striatal hypermetabolism.

Keyword

Chorea; Systemic lupus erythematous (SLE); Fluorine-18-fluorodeoxyglucose positron emission tomography (FDG-PET)

MeSH Terms

Administration, Oral
Chorea*
Female
Fluorodeoxyglucose F18
Follow-Up Studies
Humans
Lupus Erythematosus, Systemic*
Metabolism
Middle Aged
Putamen
Fluorodeoxyglucose F18
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