J Korean Neurol Assoc.
2004 Jun;22(3):255-258.
A Case of Systemic Lupus Erythematosus Presenting with Chorea: Evidence for Striatal Hypermetabolism
- Affiliations
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- 1Department of Neurology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea. jhim@amc.seoul.kr
- 2Department of Nuclear Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
Abstract
- Chorea is an uncommon clinical manifestation of Sytemic lupus erythematosus (SLE). Its pathogenic mechanism has not been clearly clarified. We report a 54-year-old woman with SLE who presented with generalized chorea as an initial manifestation. Fluorine-18-fluorodeoxyglucose (FDG) PET revealed increased metabolism in the bilateral putamen. Intravenous and oral administration of steroid markedly improved chorea. Hypermetabolism of the bilateral putamen diminished on follow-up FDG-PET after the disappearance of chorea. This study suggests that chorea in SLE is associated with striatal hypermetabolism.