J Korean Radiol Soc.  1997 Jan;36(1):83-86.

HRCT Findings of Bleomycin-Related Lung Toxicity: A Report of 2 Case

• Yi JG
• Jang WH
• Yoon DY
• Bae SH

Abstract

Many drugs can result in a variety of pathologic reactions in the lung, especially the cytotoxic drugs. Amongcytotoxic drugs bleomycin is a prototype. Bleomycin-related pulmonary toxicity is usually known as dose-dependent and can be enhanced with concurrent oxygen therapy, irradiation, or other chemotherapeutic agents. The incidence of bleomycin-induced pulmonary toxicity has been reported as varying from 2 to 46%, and 1% of fatal lung disease. We describe the radiographic and HRCT findings of bleomycin-related pulmonary toxicity developed in two patients: one in ovarian teratocarcinoma, the other malignant lymphoma patient. Chest radiographs and HRCT of these patients showed ground-glass opacities, consolidation, linear and reticular opacities, and interlobular septal thickening. These abnormalities were bilateral, and symmetrical and were found predominantly in the area of mid-and lower-lung zone.

Keyword

Bleomycin; Computed tomography(CT), high-resolution; Lung, CT; Lung, fibrosis

MeSH Terms

Bleomycin
Humans
Incidence
Lung Diseases
Lung*
Lymphoma
Oxygen
Radiography, Thoracic
Teratocarcinoma
Bleomycin
Oxygen