J Korean Soc Endocrinol.  2005 Oct;20(5):425-433. 10.3803/jkes.2005.20.5.425.

Adults Mesenchymal Stem Cells for Bone Tissue Engineering

• Won YJ

• KMID: 2200588
• DOI: http://doi.org/10.3803/jkes.2005.20.5.425

Abstract

No abstract available.

MeSH Terms

Adult*
Bone and Bones*
Humans
Mesenchymal Stromal Cells*

Figure

• 

  Fig. 1. Schematic representation of biomolecules and growth factors for osteogenic differentiation.

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  Fig. 2. Schematic presentation of clinical applications of mesenchymal stem cells for bone tissue engineering.

Reference

References

1. Fowler BL, Dall BE, Rowe DE. Complications associated with harvesting autogenous iliac bone graft. Am J Orthop. 1995; 24:895–903.

2. Goulet JA, Senunas LE, DeSilva GL, Greenfield ML. Autogenous iliac crest bone graft: complications and functional assessment. Clin Orthop Relat Res. 1997. 339:p. 76–81.

3. Parikh SN. Bone graft substitutes: past, present and future. J Postgrad Med. 2002; 48:142–148.

4. Fleming JE, Cornell CN, Muschler GF. Bone cells and matrices in orthopedic tissue engineering. Orthop Clin North Am. 2000; 31:357–374.

5. Alsberg E, Hill EE, Mooney DJ. Craniofacial tissue engineering. Crit Rev Oral Biol Med. 2001; 12:64–75.

6. Beresford JN. Osteogenic stem cells and the stromal system of bone and marrow. Clin Orthop Relat Res. 1989; 240:270–280.

7. Connolly J, Guse R, Lippiello L, Dehne R. Development of an osteogenic bone-marrow preparation. J Bone Joint Surg Am. 1989; 71:684–691.

8. Connolly JF, Guse R, Tiedeman J, Dehne R. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clin Orthop Relat Res. 1991; 266:259–270.

9. Grundel RE, Chapman MW, Yee T, Moore DC. Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna. Clin Orthop Relat Res. 1991; 266:244–258.

10. Bruder SP, Kurth AA, Shea M, Hayes WC, Jaiswal N, Kadiyala S. Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells. J Orthop Res. 1998; 16:155–162.

11. Tuan RS, Boland G, Tuli R. Adult mesenchymal stem cells and cell-based tissue engineering. Arthritis Res Ther. 2003; 5:32–45.

12. Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998; 282:1145–1147.

13. Ashton BA, Allen TD, Howlett CR, Eaglesom CC, Hattori A, Owen M. Formation of bone and cartilage by marrow stromal cells in diffusion chambers in vivo. Clin Orthop Relat Res. 1980; 151:294–307.

14. Ashton BA, Abdullah F, Cave J, Williamson M, Sy-kes BC, Couch M, Poser JW. Characterization of cells with high alkaline phosphatase activity derived from human bone and marrow: preliminary assessment of their osteogenicity. Bone. 1985; 6:313–319.

15. Friedenstein AJ, Chailakhyan RK, Gerasimov UV. Bone marrow osteogenic stem cells: in vitro cultivation and transplantation in diffusion chambers. Cell Tissue Kinet. 1987; 20:263–272.

16. Owen ME, Cave J, Joyner CJ. Clonal analysis in vitro of osteogenic differentiation of marrow CFU-F. J Cell Sci. 1987; 87(Pt5):731–738.

17. Owen M, Friedenstein AJ. Stromal stem cells: marrow-derived osteogenic precursors. Ciba Found Symp. 1988; 136:42–60.

18. Leboy PS, Beresford JN, Devlin C, Owen ME. Dexamethasone induction of osteoblast mRNAs in rat marrow stromal cell cultures. J Cell Physiol. 1991; 146:370–378.

19. Haynesworth SE, Goshima J, Goldberg VM, Caplan AI. Characterization of cells with osteogenic potential from human marrow. Bone. 1991; 13:81–88.

20. Green D, Howard D, Yang X, Kelly M, Oreffo RO. Natural marine sponge fiber skeleton: a biomimetic scaffold for human osteoprogenitor cell attachment, growth, and differentiation. Tissue Eng. 2003; 9:1159–1166.

21. Meinel L, Karageorgiou V, Fajardo R, Snyder B, Sh-inde-Patil V, Zichner L, Kaplan D, Langer R, Vun-jak-Novakovic G. Bone tissue engineering using human mesenchymal stem cells: effects of scaffold material and medium flow. Ann Biomed Eng. 2004; 32:112–122.

22. Li WJ, Tuli R, Okafor C, Derfoul A, Danielson KG, Hall DJ, Tuan RS. A three-dimensional nanofibrous scaffold for cartilage tissue engineering using human mesenchymal stem cells. Biomaterials. 2005; 26:599–609.

23. Niemeyer P, Krause U, Fellenberg J, Kasten P, Sec-kinger A, Ho AD, Simank HG. Evaluation of mineralized collagen and alpha-tricalcium phosphate as scaffolds for tissue engineering of bone using human mesenchymal stem cells. Cells Tissues Organs. 2004; 177:68–78.

24. Bosch P, Musgrave DS, Lee JY, Cummins J, Shuler T, Ghivizzani TC, Evans T, Robbins TD, Huard . Osteoprogenitor cells within skeletal muscle. J Orthop Res. 2000; 18:933–944.

25. Wada MR, Inagawa-Ogashiwa M, Shimizu S, Yasumoto S, Hashimoto N. Generation of different fates from multipotent muscle stem cells. Development. 2002; 129:2987–2995.

26. Levy MM, Joyner CJ, Virdi AS, Reed A, Triffitt JT, Simpson AH, Kenwright J, Stein H, Francis MJ. Osteoprogenitor cells of mature human skeletal muscle tissue: an in vitro study. Bone. 2001; 29:317–322.

27. Mastrogiacomo M, Derubeis AR, Cancedda R. Bone and cartilage formation by skeletal muscle derived cells. J Cell Physiol. 2005; 204:594–603.

28. Sun JS, Wu SY, Lin FH. The role of muscle-derived stem cells in bone tissue engineering. Biomaterials. 2005; 26:3953–3960.

29. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, Benhaim P, Lorenz HP, Hedrick MH. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7:211–228.

30. Halvorsen YC, Wilkison WO, Gimble JM. Adipose-derived stromal cells–their utility and potential in bone formation. Int J Obes Relat Metab Disord. 2000; 24(Suppl 4):S41–44.

31. Lee RH, Kim B, Choi I, Kim H, Choi HS, Suh K, Bae YC, Jung JS. Characterization and expression analysis of mesenchymal stem cells from human bone marrow and adipose tissue. Cell Physiol Biochem. 2004; 14:311–324.

32. Ogawa R, Mizuno H, Watanabe A, Migita M, Shimada T, Hyakusoku H. Osteogenic and chondrogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice. Biochem Biophys Res Commun. 2004; 313:871–877.

33. Halvorsen YD, Franklin D, Bond AL, Hitt DC, Auchter C, Boskey AL, Paschalis EP, Wilkison WO, Gimble JM. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng. 2001; 7:729–741.

34. Hattori H, Sato M, Masuoka K, Ishihara M, Kikuchi T, Matsui T, Takase B, Ishizuka T, Kikuchi M, Fujikawa K, Ishihara M. Osteogenic potential of human adipose tissue-derived stromal cells as an alternative stem cell source. Cells Tissues Organs. 2004; 178:2–12.

35. Nakahara H, Bruder SP, Goldberg VM, Caplan AI. In vivo osteochondrogenic potential of cultured cells derived from the periosteum. Clin Orthop Relat Res. 1990; 259:223–232.

36. Nakahara H, Dennis JE, Bruder SP, Haynesworth SE, Lennon DP, Caplan AI. In vitro differentiation of bone and hypertrophic cartilage from periosteal- derived cells. Exp Cell Res. 1991; 195:492–503.

37. Nakahara H, Goldberg VM, Caplan AI. Culture- expanded human periosteal-derived cells exhibit osteochondral potential in vivo. J Orthop Res. 1991; 9:465–476.

38. Nakahara H, Goldberg VM, Caplan AI. Culture- expanded periosteal-derived cells exhibit osteochondrogenic potential in porous calcium phosphate ceramics in vivo. Clin Orthop Relat Res. 1992; 276:291–298.

39. Noth U, Osyczka AM, Tuli R, Hickok NJ, Danielson KG, Tuan RS. Multilineage mesenchymal differentiation potential of human trabecular bone-derived cells. J Orthop Res. 2002; 20:1060–1069.

40. Osyczka AM, Noth U, Danielson KG, Tuan RS. Different osteochondral potential of clonal cell lines derived from adult human trabecular bone. Ann N Y Acad Sci. 2002; 961:73–77.

41. Young HE, Steele TA, Bray RA, Hudson J, Floyd JA, Hawkins K, Thomas K, Austin T, Edwards C, Cuzzourt J, Duenzl M, Lucas PA, Black AC Jr. Human reserve pluripotent mesenchymal stem cells are present in the connective tissues of skeletal muscle and dermis derived from fetal, adult, and geriatric donors. Anat Rec. 2001; 264:51–62.

42. Young HE, Mancini ML, Wright RP, Smith JC, Black AC Jr, Reagan CR, Lucas PA. Mesenchymal stem cells reside within the connective tissues of many organs. Dev Dyn. 1995; 202:137–144.

43. De Bari C, Dell’Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum. 2001; 44:1928–1942.

44. Vandenabeele F, De Bari C, Moreels M, Lambrichts I, Dell’Accio F, Lippens PL, Luyten FP. Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane. Arch Histol Cytol. 2003; 66:145–153.

45. Brighton CT, Lorich DG, Kupcha R, Reilly TM, Jones AR, Woodbury RA 2nd. The pericyte as a possible osteoblast progenitor cell. Clin Orthop Relat Res. 1992; 275:287–299.

46. Reilly TM, Seldes R, Luchetti W, Brighton CT. Similarities in the phenotypic expression of pericytes and bone cells. Clin Orthop Relat Res. 1998; 346:95–103.

47. Zvaifler NJ, Marinova-Mutafchieva L, Adams G, Edwards CJ, Moss J, Burger JA, Maini RN. Mesenchymal precursor cells in the blood of normal individuals. Arthritis Res. 2000; 2:477–488.

48. Roufosse CA, Direkze NC, Otto WR, Wright NA. Circulating mesenchymal stem cells. Int J Biochem Cell Biol. 2004; 36:585–597.

49. Kim JW, Kim SY, Park SY, Kim YM, Kim JM, Lee MH, Ryu HM. Mesenchymal progenitor cells in the human umbilical cord. Ann Hematol. 2004; 83:733–738.

50. Jager M, Sager M, Knipper A, Degistirici O, Fischer J, Kogler G, Wernet P, Krauspe R. In vivo and in vitro bone regeneration from cord blood derived mesenchymal stem cells. Orthopade. 2004; 33:1361–1372.

51. Zhang Y, Li CD, Jiang XX, Li HL, Tang PH, Mao N. Comparison of mesenchymal stem cells from human placenta and bone marrow. Chin Med J (Engl). 2004; 117:882–887.

52. Bellows CG, Heersche JN, Aubin JE. Determination of the capacity for proliferation and differentiation of osteoprogenitor cells in the presence and absence of dexamethasone. Dev Biol. 1990; 140:132–138.

53. Kamalia N, McCulloch CA, Tenebaum HC, Limeback H. Dexamethasone recruitment of self-renewing osteoprogenitor cells in chick bone marrow stromal cell cultures. Blood. 1992; 79:320–326.

54. Leboy PS, Vaias L, Uschmann B, Golub E, Adams SL, Pacifici M. Ascorbic acid induces alkaline phosphatase, type X collagen, and calcium deposition in cultured chick chondrocytes. J Biol Chem. 1989; 264:17281–17286.

55. Chung CH, Golub EE, Forbes E, Tokuoka T, Shapiro IM. Mechanism of action of beta-glycerophosphate on bone cell mineralization. Calcif Tissue Int. 1992; 51:305–311.

56. Tenenbaum HC, Torontali M, Sukhu B. Effects of bisphosphonates and inorganic pyrophosphate on osteogenesis in vitro. Bone. 1992; 13:249–255.

57. Bellows CG, Aubin JE, Heersche JN. Initiation and progression of mineralization of bone nodules formed in vitro: the role of alkaline phosphatase and organic phosphate. Bone Miner. 1991; 14:27–40.

58. Chang YL, Stanford CM, Keller JC. Calcium and phosphate supplementation promotes bone cell mineralization: implications for hydroxyapatite (HA)-enhanced bone formation. J Biomed Mater Res. 2000; 52:270–278.

59. Breitbart AS, Grande DA, Kessler R, Ryaby JT, Fitzsimmons RJ, Grant RT. Tissue engineered bone repair of calvarial defects using cultured periosteal cells. Plast Reconstr Surg. 1998; 101:567–574.

60. Halvorsen YD, Franklin D, Bond AL, Hitt DC, Auchter C, Boskey AL, Paschalis EP, Wilkison WO, Gimble JM. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng. 2001; 7:729–741.

61. Ohgushi H, Kitamura S, Kotobuki N, Hirose M, Machida H, Muraki K, Takakura Y. Clinical application of marrow mesenchymal stem cells for hard tissue repair. Yonsei Med J. 2004; 45(Suppl):61–67.

62. Kitamura S, Ohgushi H, Hirose M, Funaoka H, Takakura Y, Ito H. Osteogenic differentiation of human bone marrow-derived mesenchymal cells cultured on alumina ceramics. Artif Organs. 2004; 28:72–82.

63. Liu L, Won YJ, Cooke PH, Coffin DR, Fishman ML, Hicks KB, Ma PX. Pectin/poly(lactide-co-glycolide) composite matrices for biomedical applications. Biomaterials. 2004; 25:3201–3210.

64. Whang K, Tsai DC, Nam EK, Aitken M, Sprague SM, Patel PK, Healy KE. Ectopic bone formation via rhBMP-2 delivery from porous bioabsorbable polymer scaffolds. J Biomed Mater Res. 1998; 42:491–499.

65. Partridge K, Yang X, Clarke NM, Okubo Y, Bessho K, Sebald W, Howdle SM, Shakesheff KM, Oreffo RO. Adenoviral BMP-2 gene transfer in mesenchymal stem cells: in vitro and in vivo bone formation on biodegradable polymer scaffolds. Biochem Biophys Res Commun. 2002; 292:144–152.

66. Peterson B, Zhang J, Iglesias R, Kabo M, Hedrick M, Benhaim P, Lieberman JR. Healing of critically sized femoral defects, using genetically modified mesenchymal stem cells from human adipose tissue. Tissue Eng. 2005; 11:120–129.

67. Yang SH, Hsu CK, Wang KC, Hou SM, Lin FH. Tricalcium phosphate and glutaraldehyde crosslinked gelatin incorporating bone morphogenetic protein-A viable scaffold for bone tissue engineering. J Biomed Mater Res B Appl Biomater. 2005; 74:468–475.

68. Lu HH, Kofron MD, El-Amin SF, Attawia MA, Laurencin CT. In vitro bone formation using muscle-derived cells: a new paradigm for bone tissue engineering using polymer-bone morphogenetic protein matrices. Biochem Biophys Res Commun. 2003; 305:882–889.

69. Borden M, Attawia M, Khan Y, El-Amin SF, Laur-encin CT. Tissue-engineered bone formation in vivo using a novel sintered polymeric microsphere matrix. J Bone Joint Surg Br. 2004; 86:1200–1208.

70. Dunn CA, Jin Q, Taba M Jr, Franceschi RT, Bruce Rutherford R, Giannobile WV. BMP gene delivery for alveolar bone engineering at dental implant defects. Mol Ther. 2005; 11:294–299.

71. Saito N, Takaoka K. New synthetic biodegradable polymers as BMP carriers for bone tissue engineering. Biomaterials. 2003; 24:2287–2293.

72. Joyce ME, Roberts AB, Sporn MB, Bolander ME. Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol. 1990; 110:2195–2207.

73. Lind M, Schumacker B, Soballe K, Keller J, Melsen F, Bunger C. Transforming growth factor-beta enhances fracture healing in rabbit tibiae. Acta Orthop Scand. 1993; 64:553–556.

74. Arnold U, Schweitzer S, Lindenhayn K, Perka C. Optimization of bone engineering by means of growth factors in a three-dimensional matrix. J Biomed Mater Res A. 2003; 67:260–269.

75. Lieb E, Vogel T, Milz S, Dauner M, Schulz MB. Effects of transforming growth factor beta1 on bonelike tissue formation in three-dimensional cell culture. II: Osteoblastic differentiation. Tissue Eng. 2004; 10:1414–1425.

76. Steinbrech DS, Mehrara BJ, Rowe NM, Dudziak ME, Saadeh PB, Gittes GK, Longaker MT. Gene expression of insulin-like growth factors I and II in rat membranous osteotomy healing. Ann Plast Surg. 1999; 42:481–487.

77. Schmidmaier G, Wildemann B, Ostapowicz D, Kandziora F, Stange R, Haas NP, Raschke M. Long-term effects of local growth factor (IGF-I and TGF-beta 1) treatment on fracture healing. A safety study for using growth factors. J Orthop Res. 2004; 22:514–519.

78. Wildemann B, Schmidmaier G, Brenner N, Huning M, Stange R, Haas NP, Raschke M. Quantification, localization, and expression of IGF-I and TGF-beta1 during growth factor-stimulated fracture healing. Calcif Tissue Int. 2004; 74:388–397.

79. Luginbuehl V, Wenk E, Koch A, Gander B, Merkle HP, Meinel L. Insulin-like Growth Factor I-Releasing Alginate-Tricalciumphosphate Composites for Bone Regeneration. Pharm Res. 2005; 22:940–950.

80. Canalis E, McCarthy TL, Centrella M. Effects of platelet-derived growth factor on bone formation in vitro. J Cell Physiol. 1989; 140:530–537.

81. Lee YM, Park YJ, Lee SJ, Ku Y, Han SB, Klokkevold PR, Chung CP. The bone regenerative effect of platelet-derived growth factor-BB delivered with a chitosan/tricalcium phosphate sponge carrier. J Periodontol. 2000; 71:418–424.

82. Giannobile WV, Lee CS, Tomala MP, Tejeda KM, Zhu Z. Platelet-derived growth factor (PDGF) gene delivery for application in periodontal tissue engineering. J Periodontol. 2001; 72:815–823.

83. Zhu Z, Lee CS, Tejeda KM, Giannobile WV. Gene transfer and expression of platelet-derived growth factors modulate periodontal cellular activity. J Dent Res. 2001; 80:892–897.

84. Jin Q, Anusaksathien O, Webb SA, Printz MA, Giannobile WV. Engineering of tooth-supporting structures by delivery of PDGF gene therapy vectors. Mol Ther. 2004; 9:519–526.

85. Haque T, Uludag H, Zernicke RF, Winn SR, Sebald W. Bone marrow cells from normal and ovariectomized rats respond differently to basic fibroblast growth factor and bone morphogenetic protein 2 treatment in vitro. Tissue Eng. 2005; 11:634–644.