J Lab Med Qual Assur.  2009 Jun;31(1):187-198.

Age and Sex Specific Reference Ranges of Serum Type I Collagen C-telopeptide and Osteocalcin Based on Menstrual Stage

Affiliations
  • 1Department of Laboratory Medicine, Wonju Christian Hospital, Wonju, Korea. organos@daum.net
  • 2Institute of Lifelong Health, Yonsei University, Wonju, Korea.

Abstract

BACKGROUND
Bone turnover markers (BTMs) are widely used tool for monitoring the response to osteoporosis therapy, and the normal adult reference range is the baseline value for the treatment of osteoporosis with anti-resorptive agents. This study was aimed to establish age- and sex-specific reference ranges of serum osteocalcin and serum type I collagen C-telopeptide (S-CTX) in adults based on menstrual stage.
METHODS
Serum osteocalcin, S-CTX and bone mineral density (BMD) were measured in 291 adults (men: 162, women: 129), and follicle stimulating hormone (FSH) in women. Seven women whose serum FSH levels were >30 IU/mL were categorized as perimenopausal despite their regular menses.
RESULTS
Among females with normal BMD, there were no difference in serum osteocalcin and S-CTX levels between premenopausal and postmenopausal women. Females with osteopenia in pre- and postmenopausal stage showed higher serum osteocalcin and S-CTX levels than females with normal BMD. For subjects with normal BMD, reference ranges of serum osteocalcin and S-CTX were 6.4~21.6 ng/mL and 0.08~0.85 ng/mL for 30~59-year-old females. For males with normal BMD, reference ranges of serum osteocalcin were 10.1~24.3 ng/mL for 30~39 years old and 7.7~22.4 ng/mL for 40~59 years old, and reference range of CTX was 0.13~1.27 ng/mL for 30~59 years old.
CONCLUSIONS
This study will provide a redefinition of the criteria required in order to establish the normal reference ranges for BTMs. Moreover, we believe that our data will come in handy when used as normal reference ranges of BTMs in premenopausal women.

Keyword

Serum type I collagen C-telopeptide; Serum osteocalcin; Bone turnover markers; Reference range

MeSH Terms

Adult
Bone Density
Bone Diseases, Metabolic
Collagen Type I
Female
Follicle Stimulating Hormone
Humans
Male
Osteocalcin
Osteoporosis
Peptides
Reference Values
Collagen Type I
Follicle Stimulating Hormone
Osteocalcin
Peptides
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