Korean J Obstet Gynecol.  1999 Feb;42(2):329-332.

Biochemical Bone Markers in Postmenopausal Women with Hormone Replacement Therapy

• Chu HS
• Chae HD
• Kim CH
• Chang YS
• Mok JE
• Kang BM
• Chang YW
• Kang EH

Abstract

OBJECTIVES
To investigate the patterns of biochemical bone markers, such as urinary deoxypyridinoline (DPD), N-telopeptide of type I collagen (NTX), and serum osteocalcin (OC), bone-specific alkaline pbosphatase (BSAP) in postmenopansal women with hormone replacement therapy (HRT). Materials and METHOD: From July 1997 to January 1998, total 239 postmenopausal women were emolled in the present study, and 198 healthy premenopausal women with regular menstruation were served as control. The postmenopausal women were pouped into the HRT group and the non-HRT group. The women in the HRT poup have received estrogen with continuous or cyclic progestin therapy far more tban 6 months. The biochemical bone markers of all women were assayed. Results were analysed with Students t-test.
RESULTS
The urinary DPD of the non-HRT group was sigaificantly higher than both the HRT poup and the premenopausal group(5.51 +/- 2.47 vs. 3.36 +/- 1.02 and 4.01 +/- 3.86 nM/mM, p < 0.05, repectively). The urinary NTX of the non-HRT group was also higher in comparison to the HRT group and the premenopausal group(48.71 +/- 11.54 vs. 33.70 +/- 17.43 and 33.70 +/- 17.43 nM BCE/mmol, p < 0.05, repectively). However, there were no significant differences in the concentrations of serum BSAP and OC among the three poups.
CONCLUSION
The urinary DPD and NTX were more sensitive indicators of bone metabolism tban serum BSAP and OC in postmenopausal women undergoing HRT.

Keyword

Deoxypyridinoline (DPD); N-telopeptide of type I collagen (NTX); Bone-specific alkaline phosphatase (BSAP); Osteocalcin (OC); Hormone replacement therapy (HRT)

MeSH Terms

Collagen Type I
Estrogens
Female
Hormone Replacement Therapy*
Humans
Menstruation
Metabolism
Osteocalcin
Collagen Type I
Estrogens
Osteocalcin