J Lung Cancer.  2009 Dec;8(2):111-113. 10.6058/jlc.2009.8.2.111.

Primary Lung Adenocarcinoma Metastasis to the Vagina: A Case Report

• Ha SY
• Park S
• Cho EK
• Lim S
• An JS

• KMID: 2199971
• DOI: http://doi.org/10.6058/jlc.2009.8.2.111

Abstract

Lung cancer is a malignant tumor that is often fatal. Vaginal metastasis of pulmonary adenocarcinoma is very rare. To the best of our knowledge, this is the second such report worldwide and the first one from Korea. A 67-year-old woman presented with cough, excessive sputum and dyspnea that she had sufferd with for the past one year and she had a palpable lesion in the vagina. Chest CT showed diffuse bronchial wall thickening involving the left main bronchus, the left upper lobar bronchus and the lingular divisional bronchus of the left upper lobe. There were multiple, various sized nodules in both lungs, of which the largest one measured about 1.0 cm in diameter. Both lung and vaginal biopsies were performed and the masses were diagnosed as adenocarcinoma. Immunohistochemically, the tumor cells were positive for cytokeratin 7 and TTF-1, but they were negative for cytokeratin 20. We present this case of primary lung adenocarcinoma metastasis to the vagina.

Keyword

Carcinoma; Lung; Vagina; Metastasis

MeSH Terms

Adenocarcinoma
Aged
Biopsy
Bronchi
Cough
Dyspnea
Female
Humans
Keratin-20
Keratin-7
Korea
Lung
Lung Neoplasms
Neoplasm Metastasis
Sputum
Thorax
Vagina
Adenocarcinoma
Keratin-20
Keratin-7
Lung Neoplasms

Figure

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  Fig. 1. Chest CT showed the bronchial wall thickening involving the left main bronchus and the left upper lobar bronchus (arrow).

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  Fig. 2. The histological findings for the lung mass: bronchoscopic biopsy showed infiltration of atypical ovoid cells with round nuclei and plump cytoplasm (inlet) (A, H&E stain, ×40). The tumor cells were positive for TTF-1 (B, TTF-1, ×200). The histological findings for the tumor cells in the vagina: microscopically, the same atypical cells of the lung (inlet) tumor had infiltrated into the vaginal stroma (C, H&E stain, ×40). These cells revealed a positive reaction for TTF-1 (D, TTF-1, ×200).

Reference

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