J Korean Soc Endocrinol.
2000 Jun;15(2):286-290.
A Case of Osteomalacia with Long Term Carbamazepine Therapy
- Affiliations
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- 1Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea.
Abstract
- Anticonvusant therapy with any of several agents, especially phenytoin, phenobarbital, and primidone causes disturbances in bone mineral metabolism. Anticonvulsants stimulate the hepatic microsomal mixed-oxidase enzymes and hence increase the rate of clearance of vitamin D and its metabolism. The severity of clinical manifestations in any given individual appears to be a function of the combined effects of variety of factors including drug type and total drug dose, dietary vitamin D intake, sunlight exposure, and physical activity level. We report a case of osteomalacia associated with long term carbamazepine therapy in a 21-year-old male with less exposure to sunlight.
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