J Korean Orthop Res Soc.  2008 Oct;11(2):100-104.

Correlation between VEGF and Total WBC Count in the Synovial Fluid and Acute Phase Reactants in the Blood in Osteoarthritis

• Choi SW
• Jung KH
• Cho SD
• Ko SH
• Cha JR
• Lee CC
• Youm YS
• Park KB

Abstract

PURPOSE
To evaluate correlations between vascular endothelial growth factor (VEGF) which is associated with tissue remodeling and bone repair and systemic and tissue inflammation in osteoarthritis.
MATERIALS AND METHODS
Sixty patients who were above grade 2 in Kellgren-Lawrence radiologic classification of osteoarthritis were classified into group 1 (grade 2, 16 patients), group 2 (grade 3, 18 patients) and group 3 (grade 4, 26 patients). All patients were checked C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and total WBC count in the blood and VEGF and total WBC count in the synovial fluid by ELISA.
RESULTS
The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid (mean value; group 1 82.7 pg/ml, group 2 111.6 pg/ml, group 3 152.6 pg/ml). VEGF in the synovial fluid were related with total WBC count in the blood and in the synovial fluid (p=0.012, p=0.028 respectively), but not related with CRP and ESR in the blood.
CONCLUSION
The severe in osteoarthritic change in radiographs, the more VEGF in the synovial fluid. This facts suggested that there were much neovascularization and bone repair in the synovium of advanced osteoarthritis. Therefore further study elucidating mechanisms of tissue remodeling and its associated factors will be needed.

Keyword

Osteoarthritis; VEGF; C-reactive protein; ESR; WBC

MeSH Terms

Acute-Phase Proteins
Blood Sedimentation
C-Reactive Protein
Humans
Inflammation
Osteoarthritis
Synovial Fluid
Synovial Membrane
Vascular Endothelial Growth Factor A
Acute-Phase Proteins
C-Reactive Protein
Vascular Endothelial Growth Factor A