J Korean Soc Transplant.  1997 May;11(1):21-26.

Heterotopic Partial Liver Transplantation Using Inbred Cirrhotic Rat: Concept of Host Hepatectomy

• Yoo CH
• Park YR
• Rhee BW
• Kim JK
• Huh B
• Lee CH
• Park YH

Abstract

Clinical heterotopic liver transplantation(HLT) has been carried out in the several institutions since 1962. Recently, Rotterdam group reported a successful clinical series of HLT in spite of several negative viewpoints against orthotopic liver transplantation. Among the successful HLT cases till now, several occurrences of hepatocellular carcinoma in the native liver had been reported. In the current study, a thirty percent liver was transplanted heterotopically in the dimethylnitrosoamine(DMN)-induced cirrhotic rats and the feasibility of host-hepatectomy after regeneration of the graft was tested, and we are going to introduce the concept of host liver resection(HR) to the clinical auxiliary liver transplantation. Of the thirty syngeneic partial HLT with portal blood input only, 16 rats died following transplantation and three rats dies after HR. The DMN-induced cirrhotic liver specimen showed a microscopic finding of nodular cirrhosis with thick intralobular fibrous septa. Grafts examined at three posttransplant weeks appeared architecturally normal and well regenerated and the atrophied host livers were small hard showing micronodularity on the surface. Of all the animals examined, no host liver tissues were regrowing after one month following near total HR. We conclude that HLT can be performed in the clinically relevant cirrhotic rats and HR is feasible after graft regeneration and expect that this experimental model can be used for the study of cirrhosis and HLT.

Keyword

Heterotopic liver transplantation; Cirrhosis

MeSH Terms

Animals
Carcinoma, Hepatocellular
Fibrosis
Hepatectomy*
Liver Transplantation*
Liver*
Models, Theoretical
Rats*
Regeneration
Transplants