Ann Hepatobiliary Pancreat Surg.  2024 Aug;28(3):388-392. 10.14701/ahbps.24-005.

Left lobe living donor liver transplantation using the resection and partial liver segment 2–3 transplantation with delayed total hepatectomy (RAPID) procedure in cirrhotic patients: First case report in Korea

• Kim J
• Rhu J
• Lee E
• Ryu Y
• An S
• Jo SJ
• Oh N
• Han S
• Park S
• Choi GS

• KMID: 2558650
• DOI: http://doi.org/10.14701/ahbps.24-005

Abstract

In liver transplantation, the primary concern is to ensure an adequate future liver remnant (FLR) volume for the donor, while selecting a graft of sufficient size for the recipient. The living donor–resection and partial liver segment 2−3 transplantation with delayed total hepatectomy (LD−RAPID) procedure offers a potential solution to expand the donor pool for living donor liver transplantation (LDLT). We report the first case involving a cirrhotic patient with autoimmune hepatitis and hepatocellular carcinoma, who underwent left lobe LDLT using the LD−RAPID procedure. The living liver donor (LLD) underwent a laparoscopic left hepatectomy, including middle hepatic vein. The resection on the recipient side was an extended left hepatectomy, including the middle hepatic vein orifice and caudate lobe. At postoperative day 7, a computed tomography scan showed hypertrophy of the left graft from 320 g to 465 mL (i.e., a 45.3% increase in graft volume body weight ratio from 0.60% to 0.77%). After a 7-day interval, the diseased right lobe was removed in the second stage surgery. The LD−RAPID procedure using left lobe graft allows for the use of a small liver graft or small FLR volume in LLD in LDLT, which expands the donor pool to minimize the risk to LLD by enabling the donation of a smaller liver portion.

Keyword

Living donor; Tissue and organ procurement; Directed tissue donation; Transplantation

Figure

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  Fig. 1 (A) Preoperative CT image in recipient. (B) Illustration of living liver donor anatomy. (C) Left liver graft after bench procedure. (D) Operative field after first operation on the recipient. (E) CT image at postoperative day 7 after first operation on the recipient. (F) Operative field after second operation on the recipient. CT, computed tomography.

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  Fig. 2 Laboratory changes after the resection and partial liver segment 2–3 transplantation with delayed total hepatectomy procedure. (A) AST, (B) ALT, (C) INR, and (D) total bilirubin. AST, aspartate transaminase; ALT, alanine transaminase; INR, international normalized ratio.

Reference

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