Ann Liver Transplant.  2024 Nov;4(2):47-55. 10.52604/alt.24.0022.

Resection or transplantation for perihilar cholangiocarcinoma

• Kim J

• KMID: 2561848
• DOI: http://doi.org/10.52604/alt.24.0022

Abstract

An uncommon and aggressive malignancy, perihilar cholangiocarcinoma, may arise in the bile ducts at the intersection of the right and left hepatic ducts. The implementation of surgical resection and transplantation has greatly enhanced the management of the condition, resulting in improved survival rates and enhanced quality of life for patients. Nevertheless, there are still obstacles to overcome, such as restricted therapeutic alternatives for later phases, possible onset of complications, and the scarcity of donor organs. For early-stage illness, surgical resection, typically a right hepatectomy, is the recommended treatment, whereas transplantation is specified for instances that cannot be resected. Liver transplantation provides extended longevity for some patients, but it necessitates lifelong immunosuppression and entails the possibility of recurrence. The choice between resection and transplantation is contingent upon several circumstances, including the stage of the disease, the health of the patient, and the availability of a living liver donor. For patients diagnosed with perihilar cholangiocarcinoma, adopting an interdisciplinary strategy is essential to maximizing treatment success.

Keyword

Survival; Mortality; Hepatectomy; Transplantation; Living donors